ArticlePloS one2013
Reevaluating the role of the hippocampus in delay eyeblink conditioning.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Notes on the History of In Vitro Hippocampal Electrophysiology and LTP: Personal Reflections.Hippocampus · 2025Review
- The hearing hippocampus.Progress in neurobiology · 2022Review
- Reevaluating the ability of cerebellum in associative motor learning.Scientific reports · 2019Article
- Article
- Optogenetic stimulation of mPFC pyramidal neurons as a conditioned stimulus supports associative learning in rats.Scientific reports · 2015Article
- Timing and expectation of reward: a neuro-computational model of the afferents to the ventral tegmental area.Frontiers in neurorobotics · 2014Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the hippocampus in delay eyeblink conditioning (DEC) remains controversial. Here, we investigated the involvement of the hippocampus in DEC with a soft tone as the conditioned stimulus (CS) by using electrolytic lesions or muscimol inactivation of guinea pig dorsal hippocampus. Interestingly, when a soft tone was used as a CS, electrolytic lesions of the hippocampus significantly retarded acquisition of the conditioned response (CR), and muscimol infusions into hippocampus distinctly inhibited the acquisition and expression of CR, but had no significant effect on consolidation of well-learned CR. In contrast, both electrolytic lesions and muscimol inactivation of hippocampus produced no significant deficits in the CR when a loud tone was used as the CS. These results demonstrate that the hippocampus is essential for the DEC when the delay task was rendered more difficult.
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Registered trials
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