ArticlePloS one2013
Dizeez: an online game for human gene-disease annotation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Designing Videogames to Crowdsource Accelerometer Data Annotation for Activity Recognition Research.Proceedings of the ... Annual Symposium on Computer-Human Interaction in Play. ACM SIGCHI Annual Symposium on Computer-Human Interaction in Play · 2019Article
- Scientific Discovery Games for Biomedical Research.Annual review of biomedical data science · 2019Article
- Applications of crowdsourcing in health: an overview.Journal of global health · 2018Review
- Can Gamification Contribute to Computer Modeling-Driven Biomedical Research?Frontiers in physiology · 2018Article
- Developing a framework for digital objects in the Big Data to Knowledge (BD2K) commons: Report from the Commons Framework Pilots workshop.Journal of biomedical informatics · 2017Article
- Recent advances in predicting gene-disease associations.F1000Research · 2017Review
- Progress in low-resolution ab initio phasing with CrowdPhase.Acta crystallographica. Section D, Structural biology · 2016Article
- Community-Reviewed Biological Network Models for Toxicology and Drug Discovery Applications.Gene regulation and systems biology · 2016Article
- Crowdsourcing in biomedicine: challenges and opportunities.Briefings in bioinformatics · 2016Review
- Open-Phylo: a customizable crowd-computing platform for multiple sequence alignment.Genome biology · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
Structured gene annotations are a foundation upon which many bioinformatics and statistical analyses are built. However the structured annotations available in public databases are a sparse representation of biological knowledge as a whole. The rate of biomedical data generation is such that centralized biocuration efforts struggle to keep up. New models for gene annotation need to be explored that expand the pace at which we are able to structure biomedical knowledge. Recently, online games have emerged as an effective way to recruit, engage and organize large numbers of volunteers to help address difficult biological challenges. For example, games have been successfully developed for protein folding (Foldit), multiple sequence alignment (Phylo) and RNA structure design (EteRNA). Here we present Dizeez, a simple online game built with the purpose of structuring knowledge of gene-disease associations. Preliminary results from game play online and at scientific conferences suggest that Dizeez is producing valid gene-disease annotations not yet present in any public database. These early results provide a basic proof of principle that online games can be successfully applied to the challenge of gene annotation. Dizeez is available at http://genegames.org.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.