ArticlePloS one2013
Aberrant functional connectivity of resting state networks in transient ischemic attack.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Altered amygdala resting-state functional connectivity in anxiety disorders: a coordinate-based meta-analysis.Psychological medicine · 2026Pooled it
- Post-Stroke Working Memory Dysfunction: A Meta-Analysis and Systematic Review.Neuropsychology review · 2021Pooled it
- Alterations in gray matter volume and associated transcriptomics after electroconvulsive therapy in major depressive disorder.Psychological medicine · 2025Article
- Percentage Amplitude of Fluctuation Alterations in Multiple Frequency Bands in Patients With Transient Ischemic Attack: A Resting-State fMRI Study.Neural plasticity · 2025Article
- Not So Transient?: A Narrative Review on Cognitive Impairment After Transient Ischemic Attack.Stroke · 2024Review
- Constructing a Transient Ischemia Attack Model Utilizing Flexible Spatial Targeting Photothrombosis with Real-Time Blood Flow Imaging Feedback.International journal of molecular sciences · 2024Article
- Altered fractional amplitude of low-frequency fluctuations in the superior temporal gyrus: a resting-state fMRI study in anxious depression.BMC psychiatry · 2023Article
- Repeated episodes of postictal hypoxia are a mechanism for interictal cognitive impairments.Scientific reports · 2023Article
- Task-residual effective connectivity of motor network in transient ischemic attack.Communications biology · 2023Article
- Correlation between brain functional connectivity and neurocognitive function in patients with left frontal glioma.Scientific reports · 2022Article
- Altered Effective Connectivity of the Primary Motor Cortex in Transient Ischemic Attack.Neural plasticity · 2022Article
- Multiparametric and multilevel characterization of morphological alterations in patients with transient ischemic attack.Human brain mapping · 2021Article
- Altered Functional Connectivity and Cognition Persists 4 Years After a Transient Ischemic Attack or Minor Stroke.Frontiers in neurology · 2021Article
- Dynamic Functional Connectivity Alterations and Their Associated Gene Expression Pattern in Autism Spectrum Disorders.Frontiers in neuroscience · 2021Article
- The Predictive Value of Dynamic Intrinsic Local Metrics in Transient Ischemic Attack.Frontiers in aging neuroscience · 2021Article
- The Application of rs-fMRI in Vascular Cognitive Impairment.Frontiers in neurology · 2020Review
- Toward neuroimaging-based network biomarkers for transient ischemic attack.Human brain mapping · 2019Article
- The Local Brain Abnormalities in Patients With Transient Ischemic Attack: A Resting-State fMRI Study.Frontiers in neuroscience · 2019Article
- The Impact of Transient Ischemic Attack (TIA) on Brain and Behavior.Frontiers in behavioral neuroscience · 2019Review
- Canceled connections: Lesion-derived network mapping helps explain differences in performance on a complex decision-making task.Cortex; a journal devoted to the study of the nervous system and behavior · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransient ischemic attack (TIA) is usually defined as a neurologic ischemic disorder without permanent cerebral infarction. Studies have showed that patients with TIA can have lasting cognitive functional impairment. Inherent brain activity in the resting state is spatially organized in a set of specific coherent patterns named resting state networks (RSNs), which epitomize the functional architecture of memory, language, attention, visual, auditory and somato-motor networks. Here, we aimed to detect differences in RSNs between TIA patients and healthy controls (HCs).
methodsTwenty one TIA patients suffered an ischemic event and 21 matched HCs were enrolled in the study. All subjects were investigated using cognitive tests, psychiatric tests and functional magnetic resonance imaging (fMRI). Independent component analysis (ICA) was adopted to acquire the eight brain RSNs. Then one-sample t-tests were calculated in each group to gather the spatial maps of each RSNs, followed by second level analysis to investigate statistical differences on RSNs between twenty one TIA patients and 21 controls. Furthermore, a correlation analysis was performed to explore the relationship between functional connectivity (FC) and cognitive and psychiatric scales in TIA group.
resultsCompared with the controls, TIA patients exhibited both decreased and increased functional connectivity in default mode network (DMN) and self-referential network (SRN), and decreased functional connectivity in dorsal attention network (DAN), central-executive network (CEN), core network (CN), somato-motor network (SMN), visual network (VN) and auditory network (AN). There was no correlation between neuropsychological scores and functional connectivity in regions of RSNs.
conclusionsWe observed selective impairments of RSN intrinsic FC in TIA patients, whose all eight RSNs had aberrant functional connectivity. These changes indicate that TIA is a disease with widely abnormal brain networks. Our results might put forward a novel way to look into neuro-pathophysiological mechanisms in TIA patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.