SynthesisPloS one2013
Periodontal disease and risk of preeclampsia: a meta-analysis of observational studies.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Periodontitis and Preeclampsia in Pregnancy: A Systematic Review and Meta-Analysis.Maternal and child health journal · 2022Pooled it
- SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis.American journal of obstetrics and gynecology · 2022Pooled it
- Trophoblast cell response to periodontal pathogens unveils oxidative stress networks between periodontitis and pre-eclampsia: Mendelian randomization, transcriptomic analysis, and cellular experimental validation.European journal of medical research · 2025Article
- Evaluation the Risk of Preeclampsia in Periodontal Patients Compared With Healthy Individuals: A Meta-Analysis Study.International journal of dentistry · 2025Article
- Review
- Red-Complex Bacterial Levels in Pregnant Women With Preeclampsia and Chronic Periodontitis.International dental journal · 2023Article
- Adverse Pregnancy Outcomes and Maternal Periodontal Disease: An Overview on Meta-Analytic and Methodological Quality.Journal of clinical medicine · 2023Review
- The potential role of the gingival crevicular fluid biomarkers in the prediction of pregnancy complications.Frontiers in medicine · 2023Review
- Periodontal Diseases and Pregnancy: Knowledge and Clinical Practice Habits of French Midwives.Oral health & preventive dentistry · 2022Article
- Periodontitis, female fertility and conception (Review).Biomedical reports · 2022Review
- Diversity of the gut, vaginal and oral microbiome among pregnant women in South Africa with and without pre-eclampsia.Frontiers in global women's health · 2022Article
- Role of Periodontal Bacteria, Viruses, and PlacentalCurrent issues in molecular biology · 2021Article
- Periodontal Conditions and Pathogens Associated with Pre-Eclampsia: A Scoping Review.International journal of environmental research and public health · 2021Article
- Pregnancy and Dentistry: A Literature Review on Risk Management during Dental Surgical Procedures.Dentistry journal · 2021Review
- Periodontal Diseases and Adverse Pregnancy Outcomes: Review of Two Decades of Clinical Research.Oral health & preventive dentistry · 2021Review
- Does the Oral Microbiome Play a Role in Hypertensive Pregnancies?Frontiers in cellular and infection microbiology · 2020Review
- Gynecologists' Knowledge of the Association Between Periodontal Health and Female Sex Hormones.Cureus · 2019Article
- Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children's Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- The association between periodontal disease and adverse pregnancy outcomes in Northern Tanzania: a cross-sectional study.African health sciences · 2018Article
- Human infectious diseases and risk of preeclampsia: an updated review of the literature.Infection · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany epidemiological studies have found a positive association between periodontal disease (PD) and the risk of preeclampsia, but the magnitude of this association varies and independent studies have reported conflicting findings. We performed a meta-analysis to ascertain the relationship between PD and preeclampsia.
methodsThe PubMed database was searched up to January 12, 2013, for relevant observational studies on an association between PD and the risk of preeclampsia. Data were extracted and analyzed independently by two authors. The meta-analysis was performed using comprehensive meta-analysis software.
resultsThirteen observational case-control studies and two cohort studies, involving 1089 preeclampsia patients, were identified. Based on a random-effects meta-analysis, a significant association between PD and preeclampsia was identified (odds ratio = 2.79, 95% confidence interval CI, 2.01-3.01, P<0.0001).
conclusionsAlthough the causality remains unclear, the association between PD and preeclampsia may reflect the induction of PD by the preeclamptic state, or it may be part of an overall exaggerated inflammatory response to pregnancy. Larger randomized controlled trials with preeclampsia as the primary outcome and pathophysiological studies are required to explore causality and to dissect the biological mechanisms involved.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.