ArticlePloS one2013
Molecular and clinical characteristics of clonal complex 59 methicillin-resistant Staphylococcus aureus infections in Mainland China.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Insight into the molecular characteristics of community-associated Staphylococcus aureus isolates from pediatric patients in South China.BMC microbiology · 2026Article
- Genomic and virulence characteristics of Staphylococcus aureus isolates from foodborne outbreak cases.BMC microbiology · 2026Article
- Global emergence and evolution ofmSystems · 2026Article
- Antibiotic Resistance, Biofilm Formation, and Molecular Epidemiology of FoodborneFood science & nutrition · 2025Article
- Genomic characterization and outbreak investigations of methicillin-resistantFrontiers in microbiology · 2024Article
- The Plasmidomic Landscape of Clinical Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Whole genome sequencing reveals new links between spa t172/CC59 methicillin-resistant Staphylococcus aureus cases in low-endemicity region of Southwest Finland, 2007‒2016.Scientific reports · 2022Article
- Antimicrobial Resistance Genes Analysis of Publicly AvailableAntibiotics (Basel, Switzerland) · 2022Article
- The genetic feature and virulence determinant of highly virulent community-associated MRSA ST338-SCCmec Vb in China.Emerging microbes & infections · 2021Article
- Genotypic Characterization of Clinical Isolates ofPathogens (Basel, Switzerland) · 2021Article
- Clinical and molecular characteristics of Staphylococcus aureus isolated from Chinese children: association among the agr groups and genotypes, virulence genes and disease types.World journal of pediatrics : WJP · 2021Article
- A Novel Dicationic Boron Dipyrromethene-based Photosensitizer for Antimicrobial Photodynamic Therapy against Methicillin-Resistant Staphylococcus aureus.Current medicinal chemistry · 2021Article
- Monosubstituted tricationic Zn(II) phthalocyanine enhances antimicrobial photodynamic inactivation (aPDI) of methicillin-resistantEmerging microbes & infections · 2020Article
- Synthesis and In Vitro Photodynamic Activity of Cationic Boron Dipyrromethene-Based Photosensitizers against Methicillin-ResistantBiomedicines · 2020Article
- A comparative genomic analysis between methicillin-resistant Staphylococcus aureus strains of hospital acquired and community infections in Yunnan province of China.BMC infectious diseases · 2020Article
- Prevalence, Genetic Diversity, and Temporary Shifts of Inducible Clindamycin ResistanceFrontiers in microbiology · 2020Article
- NovelAntibiotics (Basel, Switzerland) · 2019Article
- Molecular typing revealed the emergence ofInfection and drug resistance · 2019Article
- Antimicrobial resistance, virulence genes profiling and molecular relatedness of methicillin-resistantInfection and drug resistance · 2019Article
- Prevalence and Characterization of Food-Related Methicillin-ResistantFrontiers in microbiology · 2019Article
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17 authors.
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Abstract
Detailed molecular analyses of Clonal Complex 59 (CC59) methicillin-resistant Staphylococcus aureus (MRSA) isolates from children in seven major cities across Mainland China were examined. A total of 110 CC59 isolates from invasive and non-invasive diseases were analyzed by multilocus sequence typing (MLST), Staphylococcus cassette chromosome mec (SCCmec) typing, staphylococcal protein A (spa) typing and pulsed-field gel electrophoresis (PFGE). Antibiotics susceptibilities, carriage of plasmids and 42 virulence genes and the expression of virulence factors were examined. ST59 (101/110, 91.8%) was the predominant sequence type (ST), while single locus variants (SLVs) belonging to ST338 (8/110, 7.3%) and ST375 (1/110, 0.9%) were obtained. Three SCCmec types were found, namely type III (2.7%), type IV (74.5%) and type V (22.7%). Seven spa types including t437, which accounted for 87.3%, were determined. Thirteen PFGE types were obtained. PFGE types A and B were the major types totally accounting for 81.8%. The dominant clone was ST59-t437-IVa (65.5%), followed by ST59-t437-V (14.5%). The positive rate of luks-PV and lukF-PV PVL encoding (pvl) gene was 55.5%. Plasmids were detected in 83.6% (92/110) of the strains. The plasmid size ranging from 23.4 kb to 50 kb was most prevalent which accounted for 83.7% (77/92). A significantly lower expression of hla was found in ST59-t437-IVa compared with ST59-t437-V. Among the 110 cases, 61.8% of the patients were less than 1 year old. A total of 90 cases (81.8%) were community-associated (CA) infections whereas 20 cases (18.2%) were hospital-associated (HA) infections. Out of the 110 patients, 36.4% (40/110) were diagnosed with invasive infectious diseases in which ST59-t437-IVa accounted for 67.5% (27/40). In brief, ST59-t437-IVa was proved as the dominant clone in CC59 MRSA strains. The carriage rate of pvl gene was high. CC59 MRSA could result in CA and HA infections. The majortiy of MRSA infection children were in young age.
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