ArticlePloS one2013
Long-term artificial sweetener acesulfame potassium treatment alters neurometabolic functions in C57BL/6J mice.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Impact of Free and Added Sugars on Cognitive Function: A Systematic Review and Meta-Analysis.Nutrients · 2023Pooled it
- Glycemic impact of non-nutritive sweeteners: a systematic review and meta-analysis of randomized controlled trials.European journal of clinical nutrition · 2018Pooled it
- Decoding the Neuroinflammatory Potential of Non-Nutritive Sweeteners Through An Integrative Computational Approach.Neurotoxicity research · 2026Article
- Synthetic Sweeteners and Human Health: An Overview of Health Risks, Vulnerable Populations, and Effects on Key Biological Systems.Medicina (Kaunas, Lithuania) · 2026Review
- GPCR systems coordinate cellular resilience against aging-associated stress.Frontiers in molecular biosciences · 2026Review
- The Relationship Between Artificial Sweetener Intake from Soft Drinks and Internet Addiction Among Students: An Analytical and Cross-Sectional Study.International journal of environmental research and public health · 2025Article
- Re-evaluation of acesulfame K (E 950) as food additive.EFSA journal. European Food Safety Authority · 2025Article
- Impact of artificial sweeteners and rare sugars on the gut microbiome.Food science and biotechnology · 2024Review
- High-fat diet mouse model receiving L-glucose supplementations propagates liver injury.Frontiers in nutrition · 2024Article
- GPR19 Coordinates Multiple Molecular Aspects of Stress Responses Associated with the Aging Process.International journal of molecular sciences · 2023Article
- The consumption pattern and perception of using artificial sweeteners among the public in Tabuk region, Saudi Arabia.Frontiers in public health · 2023Article
- Early Life Low-Calorie Sweetener Consumption Impacts Energy Balance during Adulthood.Nutrients · 2022Article
- Effect of Long-Term Intake of Nutritive and Non-Nutritive Sweeteners on Metabolic Health and Cognition in Adult Male Rats.Journal of medicinal food · 2022Article
- Early-life low-calorie sweetener consumption disrupts glucose regulation, sugar-motivated behavior, and memory function in rats.JCI insight · 2022Article
- Is the Use of Artificial Sweeteners Beneficial for Patients with Diabetes Mellitus? The Advantages and Disadvantages of Artificial Sweeteners.Nutrients · 2022Review
- The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease.International journal of molecular sciences · 2022Review
- Consumption of Non-Nutritive Sweetener, Acesulfame Potassium Exacerbates Atherosclerosis through Dysregulation of Lipid Metabolism in ApoENutrients · 2021Article
- Structural changes in endocrine pancreas of male Wistar rats due to chronic cola drink consumption. Role of PDX-1.PloS one · 2021Article
- Perspective: Standards for Research and Reporting on Low-Energy ("Artificial") Sweeteners.Advances in nutrition (Bethesda, Md.) · 2020Article
- The Impact of Artificial Sweeteners on Body Weight Control and Glucose Homeostasis.Frontiers in nutrition · 2020Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
With the prevalence of obesity, artificial, non-nutritive sweeteners have been widely used as dietary supplements that provide sweet taste without excessive caloric load. In order to better understand the overall actions of artificial sweeteners, especially when they are chronically used, we investigated the peripheral and central nervous system effects of protracted exposure to a widely used artificial sweetener, acesulfame K (ACK). We found that extended ACK exposure (40 weeks) in normal C57BL/6J mice demonstrated a moderate and limited influence on metabolic homeostasis, including altering fasting insulin and leptin levels, pancreatic islet size and lipid levels, without affecting insulin sensitivity and bodyweight. Interestingly, impaired cognitive memory functions (evaluated by Morris Water Maze and Novel Objective Preference tests) were found in ACK-treated C57BL/6J mice, while no differences in motor function and anxiety levels were detected. The generation of an ACK-induced neurological phenotype was associated with metabolic dysregulation (glycolysis inhibition and functional ATP depletion) and neurosynaptic abnormalities (dysregulation of TrkB-mediated BDNF and Akt/Erk-mediated cell growth/survival pathway) in hippocampal neurons. Our data suggest that chronic use of ACK could affect cognitive functions, potentially via altering neuro-metabolic functions in male C57BL/6J mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.