ArticlePloS one2013
Discrete pattern of burst stimulation in the ventrobasal thalamus for anti-nociception.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- A Computational Modeling Reveals That Strength of Inhibitory Input, E/I Balance, and Distance of Excitatory Input Modulate Thalamocortical Bursting Properties.Experimental neurobiology · 2019Article
- Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior.Scientific reports · 2017Article
- Reduced GABAergic transmission in the ventrobasal thalamus contributes to thermal hyperalgesia in chronic inflammatory pain.Scientific reports · 2017Article
- Differential Responses of Thalamic Reticular Neurons to Nociception in Freely Behaving Mice.Frontiers in behavioral neuroscience · 2016Article
- Thalamic Bursts and the Epic Pain Model.Frontiers in computational neuroscience · 2016Article
- Thalamic Kv 7 channels: pharmacological properties and activity control during noxious signal processing.British journal of pharmacology · 2015Article
- Changes in Activity of the Same Thalamic Neurons to Repeated Nociception in Behaving Mice.PloS one · 2015Article
- Deep brain and motor cortex stimulation.Current pain and headache reports · 2014Review
- Urethane anesthesia depresses activities of thalamocortical neurons and alters its response to nociception in terms of dual firing modes.Frontiers in behavioral neuroscience · 2013Article
- Brain stimulation patterns emulating endogenous thalamocortical input to parvalbumin-expressing interneurons reduce nociception in mice.Brain stimulationArticle
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Authors and funding
2 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The thalamus has been proposed to play a role in sensory modulation via switching between tonic and burst dual firing of individual neurons. Of the two firing modes, altered burst firing has been repeatedly implicated with pathological pain conditions, which suggests that maintaining a certain form of thalamic burst could be crucial for controlling pain. However, specific elements of burst firing that may contribute to pain control have not yet been actively investigated. Utilizing the deep brain stimulation (DBS) technique, we explored the effects of bursting properties in pain control by electrically stimulating the ventrobasal (VB) thalamus in forms of burst patterned to test different aspects of bursts during the formalin induced nociception in mice. Our results demonstrated that electrical stimulations mimicking specific burst firing properties are important in producing an anti-nociceptive effect and found that the ≤ 3 ms interval between burst pluses (intra-burst-interval: IntraBI) and ≥ 3 pulses per burst were required to reliably reduce formalin induced nociceptive responses in mice. Periodicity of IntraBI was also suggested to contribute to anti-nociception to a limited extent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.