ArticlePediatric radiology2013
MRI diffusion-weighted imaging (DWI) in pediatric small bowel Crohn disease: correlation with MRI findings of active bowel wall inflammation.
Article in Pediatric radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03340519 (Early MRI Prediction of Response to Medical Therapy and Mucosal Healing in Small Bowel Crohn's Disease), which is not on this map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early MRI Prediction of Response to Medical Therapy and Mucosal Healing in Small Bowel Crohn's Disease
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Apparent diffusion coefficient for assessing Crohn's disease activity: a meta-analysis.European radiology · 2023Pooled it
- Diagnostic performance of magnetic resonance enterography and ultrasound in children with inflammatory bowel diseases: a diagnostic test accuracy meta-analysis.European radiology · 2022Pooled it
- Pooled it
- Assessment of Activity of Crohn Disease by Diffusion-Weighted Magnetic Resonance Imaging.Medicine · 2015Trial
- MRI and Blood-based Biomarkers Are Associated With Surgery in Children and Adults With Ileal Crohn's Disease.Inflammatory bowel diseases · 2024Article
- Role of abbreviated non-contrast-enhanced MR-enterography in the evaluation of Crohn's disease activity and complications as an alternative for full protocol contrast-enhanced study: A systematic review and meta-analysis.Research in diagnostic and interventional imaging · 2023Article
- DWI ratios: New indexes for Crohn's disease activity at magnetic resonance enterography?La Radiologia medica · 2023Article
- Role of Cross-Sectional Imaging in Pediatric Inflammatory Bowel Disease.Digestive diseases and sciences · 2022Article
- Usefulness of Colon Assessment by Magnetic Resonance Enterography in Pediatric Patients with Inflammatory Bowel Disease-Retrospective Case Series.Journal of clinical medicine · 2021Article
- Paediatric gastrointestinal and hepatobiliary radiology: why do we need subspecialists, and what is new?Pediatric radiology · 2021Review
- Intensity of spinal inflammation is associated with radiological structural damage in patients with active axial spondyloarthritis.Rheumatology advances in practice · 2020Article
- Detection of Crohn's disease with diffusion images versus contrast-enhanced images in pediatric using MR enterography with histopathological correlation.La Radiologia medica · 2019Article
- ASDAS is associated with both the extent and intensity of DW-MRI spinal inflammation in active axial spondyloarthritis.RMD open · 2019Article
- Assessment of normal jejunum with diffusion-weighted imaging on MRE in children.Pediatric radiology · 2018Article
- Assessment of patency capsule retention using MR diffusion-weighted imaging.European radiology · 2017Article
- Rapid non-contrast magnetic resonance imaging for post appendectomy intra-abdominal abscess in children.Pediatric radiology · 2017Article
- Advanced imaging techniques in pediatric body MRI.Pediatric radiology · 2017Review
- Ultrasound and MRI predictors of surgical bowel resection in pediatric Crohn disease.Pediatric radiology · 2017Article
- CAIPIRINHA-accelerated T1w 3D-FLASH for small-bowel MR imaging in pediatric patients with Crohn's disease: assessment of image quality and diagnostic performance.World journal of pediatrics : WJP · 2016Article
- Diffusion weighted imaging in cystic fibrosis disease: beyond morphological imaging.European radiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRestricted diffusion on diffusion-weighted imaging (DWI) sequences during magnetic resonance enterography (MRE) has been shown in segments of bowel affected by Crohn disease. However, the exact meaning of this finding, particularly within the pediatric Crohn disease population, is poorly understood.
objectiveThe purpose of this study was to determine the significance of bowel wall restricted diffusion in children with small bowel Crohn disease by correlating apparent diffusion coefficient (ADC) values with other MRI markers of disease activity. MATERIALS AND
methodsA retrospective review of pediatric patients (≤ 18 years of age) with Crohn disease terminal ileitis who underwent MRE with DWI at our institution between May 1, 2009 and May 31, 2011 was undertaken. All of the children had either biopsy-proven Crohn disease terminal ileitis or clinically diagnosed Crohn disease, including terminal ileal involvement by imaging. The mean minimum ADC value within the wall of the terminal ileum was determined for each examination. ADC values were tested for correlation/association with other MRI findings to determine whether a relationship exists between bowel wall restricted diffusion and disease activity.
resultsForty-six MRE examinations with DWI in children with terminal ileitis were identified (23 girls and 23 boys; mean age, 14.3 years). There was significant negative correlation or association between bowel wall minimum ADC value and established MRI markers of disease activity, including degree of bowel wall thickening (R = (-)0.43; P = 0.003), striated pattern of arterial enhancement (P = 0.01), degree of arterial enhancement (P = 0.01), degree of delayed enhancement (P = 0.045), amount of mesenteric inflammatory changes (P < 0.0001) and presence of a stricture (P = 0.02). ADC values were not significantly associated with bowel wall T2-weighted signal intensity, length of disease involvement or mesenteric fibrofatty proliferation.
conclusionIncreasing bowel wall restricted diffusion (lower ADC values) is associated with multiple MRI findings that are traditionally associated with active inflammation in pediatric small bowel Crohn disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.