Evidence map›Paper›PMID 23949615›Full record

ArticleInternational journal of obesity (2005)2014

Gene expression profiling in subcutaneous, visceral and epigastric adipose tissues of patients with extreme obesity.

G S Gerhard, A M Styer, W E Strodel, S L Roesch, A Yavorek, D J Carey, G C Wood, A T Petrick, J Gabrielsen, A Ibele and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of obesity (2005), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 88 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. A novel 22-bp InDel withinAnimal biotechnology · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Mitochondrial Homeostasis in Obesity-related Hypertriglyceridemia.The Journal of clinical endocrinology and metabolism · 2022
    Article
  12. Article
  13. The impact of obesity on adipocyte-derived extracellular vesicles.Cellular and molecular life sciences : CMLS · 2021
    Review
  14. Article
  15. Review
  16. Observational
  17. Article
  18. Article
  19. Review
  20. miRNAs and Novel Food Compounds Related to the Browning Process.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

G S Gerhard1] Weis Center for Research, Danville, PA, USA [2] Department of Biochemistry and Molecular Biology and Department of Pathology and Laboratory Medicine, Pennsylvania State University, Hershey, PA, USA.
A M StyerWeis Center for Research, Danville, PA, USA.
W E StrodelDepartment of Surgery, Geisinger Medical Center, Danville, PA, USA.
S L RoeschWeis Center for Research, Danville, PA, USA.
A YavorekWeis Center for Research, Danville, PA, USA.
D J CareyWeis Center for Research, Danville, PA, USA.
G C WoodInstitute of Obesity, Geisinger Medical Center, Danville, PA, USA.
A T PetrickDepartment of Surgery, Geisinger Medical Center, Danville, PA, USA.
J GabrielsenDepartment of Surgery, Geisinger Medical Center, Danville, PA, USA.
A IbeleDepartment of Surgery, Geisinger Medical Center, Danville, PA, USA.
P BenottiInstitute of Obesity, Geisinger Medical Center, Danville, PA, USA.
D D RolstonDepartment of General and Internal Medicine, Geisinger Medical Center, Danville, PA, USA.
C D Still1] Institute of Obesity, Geisinger Medical Center, Danville, PA, USA [2] Department of Gastroenterology, Geisinger Medical Center, Danville, PA, USA.
G Argyropoulos1] Weis Center for Research, Danville, PA, USA [2] Institute of Obesity, Geisinger Medical Center, Danville, PA, USA.
Geisinger Medical Center · US

Funding

Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
Genetic determinants of NAFLD severity and progressionR01DK091601 · NIDDK · TRANSLATIONAL GENOMICS RESEARCH INST · PI DISTEFANO, JOHANNA K, GERHARD, GLENN S · 2011 to 2015
$2.9M
Genetic Determinants of Weight Loss and Resolution of Co-MorbiditiesR01DK088231 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI GERHARD, GLENN S · 2011 to 2015
$2.5M
NIDDK NIH HHS DK072488NIDDK NIH HHS DK088231NIDDK NIH HHS DK091601NIDDK NIH HHS P30 DK072488NIDDK NIH HHS R01 DK088231NIDDK NIH HHS R01 DK091601
6 · The paper itself

Abstract

objectiveThe goal of the present study was to identify differences in gene expression between SAT, VAT and EAT depots in Class III severely obese individuals.

designHuman subcutaneous (SAT) and visceral (VAT) adipose tissues exhibit differential gene expression profiles. There is little information, however, about the other proximal white adipose tissue, epigastric (EAT), in terms of its function and contribution to metabolism. SUBJECTS AND

methodsUsing RNA from adipose biospecimens obtained from Class III severely obese patients undergoing open Roux-en-Y gastric bypass surgery, we compared gene expression profiles between SAT, VAT and EAT, using microarrays validated by real-time quantitative PCR.

resultsThe three depots were found to share 1907 genes. VAT had the greatest number of genes (66) expressed exclusively in this depot, followed by SAT (23), and then EAT (14). Moreover, VAT shared more genes with EAT (65) than with SAT (38). Further analyses using ratios of SAT/EAT, VAT/EAT and SAT/VAT identified specific as well as overlapping networks and pathways of genes representing dermatological diseases, inflammation, cell cycle and growth, cancer and development. Targeted analysis of genes, having a role in adipose tissue development and function, revealed that Peroxisome proliferator-activated receptor Gamma Coactivator 1-alpha (PGC1-α) that regulates the precursor of the hormone Irisin (FNCD5) were abundantly expressed in all three fat depots, along with fibroblast growth factors (FGF) FGF1, FGF7 and FGF10, whereas, FGF19 and FGF21 were undetectable.

conclusionsThese data indicate that EAT has more in common with VAT, suggesting similar metabolic potential. The human epigastric adipose depot could have a significant functional role in metabolic diseases and should be further investigated.

Indexed as

Gastric BypassFemaleFibroblast Growth Factor 1Fibroblast Growth Factor 10Fibroblast Growth Factor 7Gene Expression ProfilingHumansInflammationIntra-Abdominal FatMaleMicroarray AnalysisMiddle AgedObesity, MorbidPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPAR gammaReal-Time Polymerase Chain ReactionFGF10 protein, humanFibroblast Growth Factor 1Fibroblast Growth Factor 10Fibroblast Growth Factor 7Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPAR gammaPPARGC1A protein, humanTranscription Factors

Identifiers

PMID23949615
PMCPMC3925764
OpenAlexW1972702131

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.