ArticleParasitology research2013
Differential diagnosis of cystic and alveolar echinococcosis using an immunochromatographic test based on the detection of specific antibodies.
Article in Parasitology research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 31 citations in OpenAlex.
- Recent advances in clinical and laboratory diagnosis of hydatid cyst: from imaging to recombinant and nanobiosensor-based approaches.Infection · 2026Review
- Hepatic alveolar echinococcosis mimicking cholangiocarcinoma: a case study.BMC infectious diseases · 2026Article
- Immunohistochemistry as a Reliable Tool for the Diagnosis of Cystic Echinococcosis in Patients from Sardinia, Italy-A Confirmatory Study.Diseases (Basel, Switzerland) · 2024Article
- NIR-II fluorescence microscopic bioimaging for intrahepatic angiography and the early detection ofFrontiers in bioengineering and biotechnology · 2023Article
- Coding and Noncoding RNA Expression Profiles of Spleen CD4Contrast media & molecular imaging · 2022Article
- MicroRNA Interference in Hepatic Host-Pathogen Interactions.International journal of molecular sciences · 2021Review
- Human microRNAs in host-parasite interaction: a review.3 Biotech · 2020Review
- Field evaluation of an immunochromatographic test for diagnosis of cystic and alveolar echinococcosis.Parasites & vectors · 2018Article
- Diagnostic Accuracy of Antigen 5-Based ELISAs for Human Cystic Echinococcosis.PLoS neglected tropical diseases · 2016Article
- Comparison of the Diagnostic Accuracy of Three Rapid Tests for the Serodiagnosis of Hepatic Cystic Echinococcosis in Humans.PLoS neglected tropical diseases · 2016Article
- Evaluation of immunochromatographic test for the detection of antibodies against Echinococcosis granulosus.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Novel recombinant multiepitope proteins for the diagnosis of asymptomatic leishmania infantum-infected dogs.PLoS neglected tropical diseases · 2015Article
- Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future?BioMed research international · 2015Review
- Evaluation of the Diagnostic Performance of Recombinant Antigen B1 for Detection of Cystic Echinococcosis Using Lateral Flow Dipstick Test.Iranian journal of parasitologyArticle
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human cystic and alveolar echinococcoses are zoonotic diseases caused by the larval stages of Echinococcus granulosus and Echinococcus multilocularis, respectively. As the diseases are co-endemic in many areas of the world, a simple and rapid test for the differential diagnosis of cystic echinococcosis (CE) and alveolar echinocoocosis (AE) is needed. Here, we describe the development of an immunochromatographic test (ICT) using crude hydatid cyst fluid and a recombinant 18-kDa protein (rEm18) as antigens for the detection of E. granulosus and E. multilocularis antibodies in serum samples. The ICT was evaluated with serum samples from 195 echinococcosis patients from different endemic areas in northwestern China. These included 144 from CE patients, 51 from AE patients, 67 from patients with other parasitic diseases, 13 from patients with serous hepatic cysts, and 60 from healthy individuals. The sensitivity and specificity of the ICT for CE were 91.0 and 96.9% and for AE were 98.0 and 99.3% with diagnostic efficiencies of 94.1 and 99.1%, respectively. No significant differences and high degrees of agreement were found between the ICT and an enzyme-linked immunosorbent assay for both CE and AE. Five serum samples from cysticercosis patients and one serum sample from a healthy control were found positive for CE with the ICT. These findings indicate that this test allows for discrimination between both forms of human echinococcosis. In conclusion, the ICT developed in this study is a promising tool for the simultaneous detection and discrimination of CE and AE. This test will be useful for serodiagnosis of CE and AE in clinical settings and screening programs.
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