Evidence map›Paper›PMID 23949252›Full record

ReviewCurrent gastroenterology reports2013

The microbiome and colorectal neoplasia: environmental modifiers of dysbiosis.

N D Turner, L E Ritchie, R S Bresalier, R S Chapkin

Abstract readReview
In one paragraph

Review in Current gastroenterology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Dietary Fiber.Advances in nutrition (Bethesda, Md.) · 2021
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Microbiome, inflammation, and cancer.Cancer journal (Sudbury, Mass.)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

N D TurnerProgram in Integrative Nutrition & Complex Disease, Center for Translational Environmental Health Research, Department of Nutrition and Food Science, Texas A&M University, College Station, TX 77843-2253, USA. n-turner@tamu.edu
L E Ritchie
R S Bresalier
R S Chapkin

Funding

Gut Microbiota and colonic gene expression: A ligran trial in humansU01CA162077 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI CHAPKIN, ROBERT STEPHEN, HULLAR, MEREDITH · 2011 to 2015
$3.2M
NCI NIH HHS U01 CA162077NCI NIH HHS U01CA162077
6 · The paper itself

Abstract

The etiology of colon cancer is complex, yet it is undoubtedly impacted by intestinal microbiota. Whether the contribution to colon carcinogenesis is generated through the presence of an overall dysbiosis or by specific pathogens is still a matter for debate. However, it is apparent that interactions between microbiota and the host are mediated by a variety of processes, including signaling cascades, the immune system, host metabolism, and regulation of gene transcription. To fully appreciate the role of microbiota in colon carcinogenesis, it will be necessary to expand efforts to define populations in niche environments, such as colonic crypts, explore cross talk between the host and the microbiota, and more completely define the metabolomic profile of the microbiota. These efforts must be pursued with appreciation that dietary substrates and other environmental modifiers mediate changes in the microbiota, as well as their metabolism and functional characteristics.

Indexed as

BacteriaBreast FeedingColonColorectal NeoplasmsDietDysbiosisEnvironmentHumansInfant, NewbornIntestinal MucosaIntestinesMicrobiotaSignal TransductionSymbiosis

Identifiers

PMID23949252
PMCPMC3807587

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.