ArticleJournal of assisted reproduction and genetics2013
Preimplantation genetic screening (PGS) with Comparative genomic hybridization (CGH) following day 3 single cell blastomere biopsy markedly improves IVF outcomes while lowering multiple pregnancies and miscarriages.
Article in Journal of assisted reproduction and genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Pregnancy and child developmental outcomes after preimplantation genetic screening: a meta-analytic and systematic review.World journal of pediatrics : WJP · 2018Pooled it
- Can Comprehensive Chromosome Screening Technology Improve IVF/ICSI Outcomes? A Meta-Analysis.PloS one · 2015Pooled it
- Predicting cell properties with AI from 3D imaging flow cytometer data.Scientific reports · 2025Article
- The first clinical validation of whole-genome screening on standard trophectoderm biopsies of preimplantation embryos.F&S reports · 2024Article
- Article
- Different Strategies of Preimplantation Genetic Testing for Aneuploidies in Women of Advanced Maternal Age: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2021Review
- ChromInst: A single cell sequencing technique to accomplish pre-implantation comprehensive chromosomal screening overnight.PloS one · 2021Article
- A Rapid NGS-Based Preimplantation Genetic Testing for Chromosomal Abnormalities in Day-3 Blastomere Biopsy Allows Embryo Transfer Within the Same Treatment Cycle.Frontiers in genetics · 2021Article
- Article
- Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity†.Biology of reproduction · 2020Article
- Pregnancy rates after pre-implantation genetic screening for aneuploidy are only superior when trophectoderm biopsy is performed on hatching embryos.Journal of assisted reproduction and genetics · 2019Article
- Noninvasive chromosome screening of human embryos by genome sequencing of embryo culture medium for in vitro fertilization.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Recent advances in preimplantation genetic diagnosis and screening.Journal of assisted reproduction and genetics · 2016Review
- Discrepant diagnosis rate of array comparative genomic hybridization in thawed euploid blastocysts.Journal of assisted reproduction and genetics · 2016Article
- A pilot proof-of-principle study to compare fresh and vitrified cycle preimplantation genetic screening by chromosome microarray and next generation sequencing.Molecular cytogenetics · 2016Article
- The IMSI Procedure Improves Laboratory and Clinical Outcomes Without Compromising the Aneuploidy Rate When Compared to the Classical ICSI Procedure.Clinical medicine insights. Reproductive health · 2015Article
- Current status of comprehensive chromosome screening for elective single-embryo transfer.Obstetrics and gynecology international · 2014Review
- New tools for embryo selection: comprehensive chromosome screening by array comparative genomic hybridization.BioMed research international · 2014Article
- Erratum: Relationship between morphology, euploidy and implantation potential of cleavage and blastocyst stage embryos.Journal of human reproductive sciencesArticle
- Relationship Between Morphology, Euploidy and Implantation Potential of Cleavage and Blastocyst Stage Embryos.Journal of human reproductive sciencesArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine benefits of cleavage-stage preimplantation genetic screening (PGS) by array comparative genomic hybridization (CGH).
methodsA retrospective case-control study was performed at a tertiary care university-affiliated medical center. Implantation rate was looked at as a primary outcome. Secondary outcomes included clinical and ongoing pregnancy rates, as well as multiple pregnancy and miscarriage rates. Thirty five patients underwent 39 fresh cycles with PGS by aCGH and 311 similar patients underwent 394 invitro fertilization cycles. RESULT(S): The implantation rate in the CGH group doubled when compared to the control group (52.63 % vs. 19.15 %, p = < 0.001), clinical pregnancy rate was higher (69.23 % vs. 43.91 %, p = 0.0002), ongoing pregnancy rate almost doubled (61.54 % vs. 32.49 %, p = < 0.0001), multiple pregnancy rate decreased (8.33 % vs. 34.38 %, p = 0.0082) and miscarriage rate trended lower (11.11 % vs. 26.01 %, p = 0.13).
conclusionCleavage stage PGS with CGH is a feasible and safe option for aneuploidy screening that shows excellent outcomes when used in fresh cycles. This is the first report of cleavage stage PGS by CGH showing improved ongoing pregnancy rates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.