Evidence map›Paper›PMID 23949035›Full record

Trial reportNeuroRehabilitation2013

Brain stimulation paired with novel locomotor training with robotic gait orthosis in chronic stroke: a feasibility study.

Megan M Danzl, Kenneth C Chelette, Kara Lee, Dana Lykins, Lumy Sawaki

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in NeuroRehabilitation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03688165 (The Effects of Gait Rehabilitation Using Treadmill-based Robotics), which is not on this map. Cited by 36 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 13 pooled it
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03688165 completednot on this mapstarted 2018, after this paper: background citation

The Effects of Gait Rehabilitation Using Treadmill-based Robotics (Exoskeletons or End-effectors) Versus Traditional Physical Therapy in Stroke Survivors: a Multicenter Controlled Non-randomized Trial

Typeobservational_patient_registrySponsorIRCCS San Raffaele RomaRan2018 to 2022Enrolled87ConditionsStroke, Acute Stroke, Chronic StrokeArmsTreadmill-based Robotic Gait Training, Traditional Over-ground Gait Training
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 13 syntheses or guidelines pooled it, 92 citations in OpenAlex.

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  9. Transcranial direct current stimulation for improving ambulation after stroke: a systematic review and meta-analysis.International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation · 2020
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  12. Electromechanical-assisted training for walking after stroke.The Cochrane database of systematic reviews · 2017
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  16. Breaking the ice to improve motor outcomes in patients with chronic stroke: a retrospective clinical study on neuromodulation plus robotics.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Megan M DanzlDepartment of Rehabilitation Sciences, University of Kentucky, Lexington, KY 40504, USA.
Kenneth C Chelette
Kara Lee
Dana Lykins
Lumy Sawaki
University of Kentucky · USCardinal Hill Rehabilitation Hospital · US

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
KENTUCKY CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCEUL1RR033173 · NCRR · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2011 to 2011
$3.5M
NCATS NIH HHS UL1 TR000117NCATS NIH HHS UL1 TR001998NCRR NIH HHS UL1 RR033173NCRR NIH HHS UL1RR033173
6 · The paper itself

Abstract

objectives1) To investigate the feasibility of combining transcranial direct current stimulation (tDCS) to the lower extremity (LE) motor cortex with novel locomotor training to facilitate gait in subjects with chronic stroke and low ambulatory status, and 2) to obtain insight from study subjects and their caregivers to inform future trial design.

methodsDouble-blind, randomized controlled study with additional qualitative exploratory descriptive design. One-month follow-up.10 subjects with stroke were recruited and randomized to active tDCS or sham tDCS for 12 sessions. Both groups participated in identical locomotor training with a robotic gait orthosis (RGO) following each tDCS session. RGO training protocol was designed to harness cortical neuroplasticity. Data analysis included assessment of functional and participation outcome measures and qualitative thematic analysis.

resultsEight subjects completed the study. Both groups demonstrated trends toward improvement, but the active tDCS group showed greater improvement than the sham group. Qualitative analyses indicated beneficial effects of this combined intervention.

conclusionsIt is feasible to combine tDCS targeting the LE motor cortex with our novel locomotor training. It appears that tDCS has the potential to enhance the effectiveness of gait training in chronic stroke. Insights from participants provide additional guidance in designing future trials.

Indexed as

Stroke RehabilitationTranscranial Magnetic StimulationAdultAgedAged, 80 and overChronic DiseaseDouble-Blind MethodFeasibility StudiesFemaleGait Disorders, NeurologicHumansLower ExtremityMaleMiddle AgedOrthotic DevicesRobotics

Identifiers

PMID23949035
PMCPMC4349529
OpenAlexW1578152811

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.