ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2014
Skeletal findings in the first 12 months following initiation of glucocorticoid therapy for pediatric nephrotic syndrome.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study (STOPP-CIS)
The Impact of Glomerular Disorders on Bone Quality and Strength
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Current status and research hotspots of pediatric nephrotic syndrome: a bibliometric analysis (2011-2025).Frontiers in pediatrics · 2026Pooled it
- The effect of vitamin D and calcium supplementation in pediatric steroid-sensitive nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2017Trial
- Common normal variants of pediatric vertebral development that mimic fractures: a pictorial review from a national longitudinal bone health study.Pediatric radiology · 2015Trial
- Osteoporotic vertebral compression fracture in patients with childhood-onset lupus nephritis: prevalence and risk factors.Archives of osteoporosis · 2025Article
- Risk factors associated with low bone mineral density and childhood osteoporosis in a population undergoing skeletal growth: a cross-sectional analytic study.Frontiers in endocrinology · 2025Article
- Effect of 2-6 weeks of systemic steroids on bone mineral density in children.Clinical and experimental pediatrics · 2022Article
- Part I: Which Child with a Chronic Disease Needs Bone Health Monitoring?Current osteoporosis reports · 2021Review
- Bone mass and vertebral fractures in South African children on prolonged oral glucocorticoids for chronic non-malignant illnesses.Bone reports · 2021Article
- Calcium, Vitamin D, and Bone Derangement in Nephrotic Syndrome.Journal of the ASEAN Federation of Endocrine Societies · 2021Article
- [Clinical features of catch-up growth after kidney transplantation in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Expert panel consensus recommendations for diagnosis and treatment of secondary osteoporosis in children.Pediatric rheumatology online journal · 2020Article
- Glucocorticoid-Induced Osteoporosis: Why Kids Are Different.Frontiers in endocrinology · 2020Review
- Canadian Society of Nephrology Commentary on the Kidney Disease Improving Global Outcomes 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder.Canadian journal of kidney health and disease · 2020Article
- Management of primary and secondary osteoporosis in children.Therapeutic advances in musculoskeletal disease · 2020Review
- Bone Health in Glomerular Kidney Disease.Current osteoporosis reports · 2019Review
- The management of osteoporosis in children.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Review
- Incident Vertebral Fractures and Risk Factors in the First Three Years Following Glucocorticoid Initiation Among Pediatric Patients With Rheumatic Disorders.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Effect of glucocorticoids on growth and bone mineral density in children with nephrotic syndrome.European journal of pediatrics · 2015Article
- Bone health in children and adolescents with steroid-sensitive nephrotic syndrome assessed by DXA and QUS.Pediatric nephrology (Berlin, Germany) · 2014Article
- Urtica dioica extract attenuates depressive like behavior and associative memory dysfunction in dexamethasone induced diabetic mice.Metabolic brain disease · 2014Article
Corrections and comments
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Authors and funding
29 authors at 11 institutions in 1 country.
Funding
Abstract
unlabelledIncident vertebral fractures and lumbar spine bone mineral density (BMD) were assessed in the 12 months following glucocorticoid initiation in 65 children with nephrotic syndrome. The incidence of vertebral fractures was low at 12 months (6 %) and most patients demonstrated recovery in BMD Z-scores by this time point.
introductionVertebral fracture (VF) incidence following glucocorticoid (GC) initiation has not been previously reported in pediatric nephrotic syndrome.
methodsVF was assessed on radiographs (Genant method); lumbar spine bone mineral density (LS BMD) was evaluated by dual-energy X-ray absorptiometry.
resultsSixty-five children were followed to 12 months post-GC initiation (median age, 5.4 years; range, 2.3-17.9). Three of 54 children with radiographs (6 %; 95 % confidence interval (CI), 2-15 %) had incident VF at 1 year. The mean LS BMD Z-score was below the healthy average at baseline (mean ± standard deviation (SD), -0.5 ± 1.1; p = 0.001) and at 3 months (-0.6 ± 1.1; p < 0.001), but not at 6 months (-0.3 ± 1.3; p = 0.066) or 12 months (-0.3 ± 1.2; p = 0.066). Mixed effect modeling showed a significant increase in LS BMD Z-scores between 3 and 12 months (0.22 SD; 95 % CI, 0.08 to 0.36; p = 0.003). A subgroup (N = 16; 25 %) had LS BMD Z-scores that were ≤-1.0 at 12 months. In these children, each additional 1,000 mg/m(2) of GC received in the first 3 months was associated with a decrease in LS BMD Z-score by 0.39 at 12 months (95 % CI, -0.71 to -0.07; p = 0.017).
conclusionsThe incidence of VF at 1 year was low and LS BMD Z-scores improved by 12 months in the majority. Twenty-five percent of children had LS BMD Z-scores ≤-1.0 at 12 months. In these children, LS BMD Z-scores were inversely associated with early GC exposure, despite similar GC exposure compared to the rest of the cohort.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.