ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2014
Palliative epilepsy surgery in Aicardi syndrome: a case series and review of literature.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 11 citations in OpenAlex.
- Case Report: Subtotal Hemispherotomy Modulates the Epileptic Spasms in Aicardi Syndrome.Frontiers in neurology · 2021Article
- Palliative epilepsy surgery in Dravet syndrome-case series and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Review
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3 authors at 2 institutions in 1 country.
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Abstract
purposeAicardi syndrome (AS) is a severe neurodevelopmental disorder characterized by the triad of seizures, agenesis of corpus callosum, and chorioretinal lacunae. Seizures in AS are typically frequent, of various types, and refractory to medical therapy. Optimal treatment of seizures in AS remains undetermined.
methodsWe report a series of four patients with Aicardi syndrome who underwent surgical management of their epilepsy including two with corpus callosotomy (CC) of a partial corpus callosum and three with vagus nerve stimulator implantation.
resultsSeizure outcome was variable and ranged from near complete resolution of seizures to worsening of seizure profile. The most favorable seizure outcome was seen in a patient with partial agenesis of the corpus callosum treated with CC.
conclusionsSeizure outcome following CC or vagus nerve stimulation in patients with Aicardi syndrome is variable. Although palliative epilepsy surgery may result in improvement in the seizure profile in some patients, studies on larger patient cohorts are needed to identify the precise role that surgery may play in the multidisciplinary approach to controlling seizures in Aicardi syndrome.
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