Observational studyEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2014
Continued declining incidence and improved survival of progressive multifocal leukoencephalopathy in HIV/AIDS patients in the current era.
Observational study in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Article
- Long-term prognosis and overall mortality in patients with progressive multifocal leukoencephalopathy.Scientific reports · 2023Article
- Promise and Challenges of Checkpoint Inhibitor Therapy for Progressive Multifocal Leukoencephalopathy in HIV.Current HIV/AIDS reports · 2022Review
- Checkpoint inhibitors and progressive multifocal leukoencephalopathy: friends of foes?Annals of translational medicine · 2019Article
- Not a Disease of the Past: A Case Series of Progressive Multifocal Leukoencephalopathy in the Established Antiretroviral Era.AIDS research and human retroviruses · 2019Article
- Progressive multifocal leukoencephalopathy in Finland: a cross-sectional registry study.Journal of neurology · 2019Article
- Progressive Multifocal Leukoencephalopathy: Current Insights.Degenerative neurological and neuromuscular disease · 2019Review
- JC Virus Granule Cell Neuronopathy as AIDS-Presenting Illness.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2018Article
- Emerging Understanding of the Mechanism of Action for Dimethyl Fumarate in the Treatment of Multiple Sclerosis.Frontiers in neurology · 2018Review
- Exploring the role of NCCR variation on JC polyomavirus expression from dual reporter minicircles.PloS one · 2018Article
- Article
- Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses.Cell reports · 2017Article
- Progressive multifocal leukoencephalopathy in patients treated with fumaric acid esters: a review of 19 cases.Journal of neurology · 2017Review
- HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment.Nature reviews. Neurology · 2016Review
- Treatment of Progressive Multifocal Leukoencephalopathy With Mirtazapine.Clinical drug investigation · 2016Review
- Predictors and characteristics of seizures in survivors of progressive multifocal leukoencephalopathy.Journal of neurovirology · 2016Article
- Detection of cases of progressive multifocal leukoencephalopathy associated with new biologicals and targeted cancer therapies from the FDA's adverse event reporting system.Expert opinion on drug safety · 2016Article
- CNS infections in patients with hematological disorders (including allogeneic stem-cell transplantation)-Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO).Annals of oncology : official journal of the European Society for Medical Oncology · 2016Article
- Predictors of survival and functional outcomes in natalizumab-associated progressive multifocal leukoencephalopathy.Journal of neurovirology · 2015Article
- Progressive Multifocal Leukoencephalopathy.F1000Research · 2015Review
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7 authors.
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Abstract
To evaluate the situation and perspectives of progressive multifocal leukoencephalopathy (PML) in human immunodeficiency virus (HIV)-infected patients, we investigated changes in the incidence, causes, and long-term outcome of this disease in 72 acquired immunodeficiency syndrome (AIDS) patients who were diagnosed with PML from 1996 to 2011. Patients were classified according to the date of diagnosis in the first (1996-2000, n = 35), second (2001-2006, n = 26), and recent or third highly active antiretroviral therapy (HAART) period (2007-2011, n = 11). Overall, the incidence of PML decreased from 14.8 cases/1,000 patients/year in 1996 to 2.6 in 2005 and 0.8 in 2011, and nearly two-thirds of recent cases (64 %) were observed in HIV patients not attending clinical visits. The baseline median CD4+ count was higher in recently PML-diagnosed patients (77 vs. 86 vs. 101 cells/mm(3); p < 0.01), and this fact was associated with a cerebrospinal fluid (CSF) inflammatory profile (from 11 to 31 to 55 %, p = 0.007) and with a significantly longer survival (attributable death, 54 vs. 35 vs. 36 %, respectively, p < 0.01). Thus, the overall 1-year and 3-year survival rates were 55 and 50 %, respectively, increasing to 79 % at 1 year for patients with CD4+ count above 100 cells/mm(3) at diagnosis. In a Cox regression analysis, an older age (hazard ratio, HR 0.76), a baseline CD4+ count above 100 cells/mm(3) (HR 0.33), and a CSF inflammatory profile (HR 0.12) were significantly associated with a longer survival. The clinical presentation and outcome of PML in AIDS patients continue to change dramatically. Now, a declining incidence and long-term survival is observed.
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