ArticlePhysiology & behavior2013
Cocaine self-administration punished by i.v. histamine in rat models of high and low drug abuse vulnerability: effects of saccharin preference, impulsivity, and sex.
Article in Physiology & behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Distinct ensembles in the prelimbic cortex track different measures of motivation for cocaine and water reinforcers.bioRxiv : the preprint server for biology · 2026Article
- Examining the predictive validity of alcohol-seeking following punishment-imposed abstinence in mice.Alcohol, clinical & experimental research · 2025Article
- Increased responsiveness to punishment of cocaine self-administration after experience with high punishment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Females develop features of an addiction-like phenotype sooner during withdrawal than males.Psychopharmacology · 2021Article
- Resurgence of alcohol seeking following abstinence induced by punishment in male and female rats.Behavioural brain research · 2021Article
- Aversion-resistant fentanyl self-administration in mice.Psychopharmacology · 2021Article
- Compulsive sucrose- and cocaine-seeking behaviors in male and female Wistar rats.Psychopharmacology · 2018Article
- Decrease of cocaine, but not heroin, self-administration and relapse by the tyrosine kinase inhibitor masitinib in male Sprague Dawley rats.Psychopharmacology · 2018Article
- Modeling the development of drug addiction in male and female animals.Pharmacology, biochemistry, and behavior · 2018Review
- How to study sex differences in addiction using animal models.Addiction biology · 2016Review
- Cocaine self-administration punished by intravenous histamine in adolescent and adult rats.Behavioural pharmacology · 2015Article
- Intracranial self-stimulation reward thresholds during morphine withdrawal in rats bred for high (HiS) and low (LoS) saccharin intake.Brain research · 2015Article
- Sex Differences in Behavioral Dyscontrol: Role in Drug Addiction and Novel Treatments.Frontiers in psychiatry · 2015Review
- Prolonged withdrawal following cocaine self-administration increases resistance to punishment in a cocaine binge.Scientific reports · 2014Article
- Cocaine-, caffeine-, and stress-evoked cocaine reinstatement in high vs. low impulsive rats: treatment with allopregnanolone.Drug and alcohol dependence · 2014Article
- Assessment of the kappa opioid agonist, salvinorin A, as a punisher of drug self-administration in monkeys.Psychopharmacology · 2014Article
- Assessment of the effects of contingent histamine injections on the reinforcing effectiveness of cocaine using behavioral economic and progressive-ratio designs.Psychopharmacology · 2014Article
- Cocaine-induced c-Fos expression in rats selectively bred for high or low saccharin intake and in rats selected for high or low impulsivity.Behavioural brain research · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A key feature of substance use disorders is continued drug consumption despite aversive consequences. This has been modeled in the animal laboratory by pairing drug self-administration with electric shock, thereby punishing drug intake (Deroche-Gamonet et al. 2004). In the present experiments, we examined the effects of punishment on i.v. cocaine self-administration by adding histamine to the cocaine solution with three different animal models of high and low vulnerability to drug abuse: rats selectively bred for high (HiS) and low (LoS) saccharin consumption, rats selected for high (HiI) and low (LoI) impulsivity, and sex differences. Animals were allowed to self-administer cocaine (0.4 mg/kg/infusion) to establish a baseline of operant responding. Histamine (4.0mg/kg/infusion) was then added directly into the cocaine solution and its consequent effects on self-administration were compared to baseline. The histamine+cocaine solution was then replaced with a cocaine-only solution, and the rats' operant responding was again compared to baseline. Concurrent histamine exposure was effective in reducing cocaine consumption in all groups of rats; however, LoS and female rats took longer to return to baseline levels of cocaine consumption after histamine was removed compared to HiS and male rats. These data suggest that the reduction of drug self-administration by aversive consequences may differ in groups that vary in drug use vulnerability . Such results may inform pharmacological strategies that enhance the negative aspects of drug consumption.
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