ReviewCirculation research2013
New and TALENted genome engineering toolbox.
Review in Circulation research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- The importance of understanding the ethology and ecology of the zebrafish, and of other fish species, in experimental research.Biologia futura · 2025Review
- Review
- Computational Analysis of Cardiac Contractile Function.Current cardiology reports · 2022Review
- Genetic insights, disease mechanisms, and biological therapeutics for Waardenburg syndrome.Gene therapy · 2022Review
- An insight on established retinal injury mechanisms and prevalent retinal stem cell activation pathways in vertebrate models.Animal models and experimental medicine · 2021Review
- Knockout of zebrafish desmin genes does not cause skeletal muscle degeneration but alters calcium flux.Scientific reports · 2021Article
- Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy.Science translational medicine · 2020Article
- Fishing for understanding: Unlocking the zebrafish gene editor's toolbox.Methods (San Diego, Calif.) · 2018Review
- Robust activation of microhomology-mediated end joining for precision gene editing applications.PLoS genetics · 2018Article
- Role of Molecular Biology in Cancer Treatment: A Review Article.Iranian journal of public health · 2017Review
- Fishing for cures: The alLURE of using zebrafish to develop precision oncology therapies.NPJ precision oncology · 2017Article
- Exon- and contraction-dependent functions of titin in sarcomere assembly.Development (Cambridge, England) · 2016Article
- Allele-Specific Quantitative PCR for Accurate, Rapid, and Cost-Effective Genotyping.Human gene therapy · 2016Article
- FusX: A Rapid One-Step Transcription Activator-Like Effector Assembly System for Genome Science.Human gene therapy · 2016Article
- ModelingJournal of cardiovascular development and disease · 2016Article
- Review
- The CRISPR road: from bench to bedside on an RNA-guided path.Annals of translational medicine · 2015Article
- Cardiac transcriptome and dilated cardiomyopathy genes in zebrafish.Circulation. Cardiovascular genetics · 2015Article
- Review
- Using engineered endonucleases to create knockout and knockin zebrafish models.Methods in molecular biology (Clifton, N.J.) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Recent advances in the burgeoning field of genome engineering are accelerating the realization of personalized therapeutics for cardiovascular disease. In the postgenomic era, sequence-specific gene-editing tools enable the functional analysis of genetic alterations implicated in disease. In partnership with high-throughput model systems, efficient gene manipulation provides an increasingly powerful toolkit to study phenotypes associated with patient-specific genetic defects. Herein, this review emphasizes the latest developments in genome engineering and how applications within the field are transforming our understanding of personalized medicine with an emphasis on cardiovascular diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.