ArticleActa biomaterialia2013
Predictive biomechanical analysis of ascending aortic aneurysm rupture potential.
Article in Acta biomaterialia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 104 citations in OpenAlex.
- Influence of Hypertension on the Regional Elastic Properties of Ascending Thoracic Aortic Aneurysms with Bicuspid Aortic Valves.Annals of biomedical engineering · 2026Article
- Impact of Dynamic Axial Stretching on the Arterial Pulse Wave Velocity: Physical Foundation and Clinical Implications.Annals of biomedical engineering · 2026Article
- In vivo aortic elasticity measurement using electrocardiogram-gated computed tomography: validation with ex vivo loading test.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Beta Blockers as Primary and Secondary Prevention for Aortic Dissections in Nonsyndromic Patients With Hypertension.Journal of the American Heart Association · 2025Article
- Numerical Evaluation of Abdominal Aortic Aneurysms Utilizing Finite Element Method.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Stiffness matters: Improved failure risk assessment of ascending thoracic aortic aneurysms.JTCVS open · 2023Article
- Effect of Nonlinear Hyperelastic Property of Arterial Tissues on the Pulse Wave Velocity Based on the Unified-Fiber-Distribution (UFD) Model.Annals of biomedical engineering · 2023Article
- Synergistic Integration of Deep Neural Networks and Finite Element Method with Applications of Nonlinear Large Deformation Biomechanics.Computer methods in applied mechanics and engineering · 2023Article
- PyTorch-FEA: Autograd-enabled finite element analysis methods with applications for biomechanical analysis of human aorta.Computer methods and programs in biomedicine · 2023Article
- An image-based approach for the estimation of arterial local stiffnessFrontiers in bioengineering and biotechnology · 2023Article
- Ascending aorta mechanics and dimensions in aortopathy - from science to application.Indian journal of thoracic and cardiovascular surgery · 2022Review
- Patient-Specific Analysis of Ascending Thoracic Aortic Aneurysm with the Living Heart Human Model.Bioengineering (Basel, Switzerland) · 2021Article
- Potential damage in pulmonary arterial hypertension: An experimental study of pressure-induced damage of pulmonary artery.Journal of biomedical materials research. Part A · 2021Article
- Relative strain is a novel predictor of aneurysmal degeneration of the thoracic aorta: An ex vivo mechanical study.JVS-vascular science · 2021Article
- New indicators for systematic assessment of aortic morphology: a narrative review.Journal of thoracic disease · 2021Review
- A generic physics-informed neural network-based constitutive model for soft biological tissues.Computer methods in applied mechanics and engineering · 2020Article
- Multimodality Imaging-Based Characterization of Regional Material Properties in a Murine Model of Aortic Dissection.Scientific reports · 2020Article
- Biomechanics of aortic wall failure with a focus on dissection and aneurysm: A review.Acta biomaterialia · 2019Review
- Identification of in vivo nonlinear anisotropic mechanical properties of ascending thoracic aortic aneurysm from patient-specific CT scans.Scientific reports · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Aortic aneurysm is a leading cause of death in adults, often taking lives without any premonitory signs or symptoms. Adverse clinical outcomes of aortic aneurysm are preventable by elective surgical repair; however, identifying at-risk individuals is difficult. The objective of this study was to perform a predictive biomechanical analysis of ascending aortic aneurysm (AsAA) tissue to assess rupture risk on a patient-specific level. AsAA tissues, obtained intra-operatively from 50 patients, were subjected to biaxial mechanical and uniaxial failure tests to obtain their passive elastic mechanical properties. A novel analytical method was developed to predict the AsAA pressure-diameter response as well as the aortic wall yield and failure responses. Our results indicated that the mean predicted AsAA diameter at rupture was 5.6 ± 0.7 cm, and the associated blood pressure to induce rupture was 579.4 ± 214.8 mmHg. Statistical analysis showed significant positive correlation between aneurysm tissue compliance and predicted risk of rupture, where patients with a pressure-strain modulus ≥100 kPa may be nearly twice as likely to experience rupture than patients with more compliant aortic tissue. The mechanical analysis of pre-dissection patient tissue properties established in this study could predict the "future" onset of yielding and rupture in AsAA patients. The analysis results implicate decreased tissue compliance as a risk factor for AsAA rupture. The presented methods may serve as a basis for the development of a pre-operative planning tool for AsAA evaluation, a tool currently unavailable.
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