ArticleReproductive biology and endocrinology : RB&E2013
FMR1-dependent variability of ovarian aging patterns is already apparent in young oocyte donors.
Article in Reproductive biology and endocrinology : RB&E, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- The impact of FMR1 gene mutations on human reproduction and development: a systematic review.Journal of assisted reproduction and genetics · 2016Pooled it
- The association ofArchives of medical science : AMS · 2021Article
- Effect of race and ethnicity on utilization and outcomes of assisted reproductive technology in the USA.Reproductive biology and endocrinology : RB&E · 2017Article
- Association of skewed X-chromosome inactivation with FMR1 CGG repeat length and anti-Mullerian hormone levels: a cohort study.Reproductive biology and endocrinology : RB&E · 2017Article
- Correlation of normal-range FMR1 repeat length or genotypes and reproductive parameters.Journal of assisted reproduction and genetics · 2016Article
- Maximizing the clinical utility of antimüllerian hormone testing in women's health.Current opinion in obstetrics & gynecology · 2014Review
- Utilizing FMR1 gene mutations as predictors of treatment success in human in vitro fertilization.PloS one · 2014Article
- How the FMR1 gene became relevant to female fertility and reproductive medicine.Frontiers in genetics · 2014Article
- FMR1 premutation is an uncommon explanation for premature ovarian failure in Han Chinese.PloS one · 2014Article
- An Update on Ovarian Aging and Ovarian Reserve Tests.International journal of fertility & sterilityReview
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Authors and funding
9 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundHypothesizing that redundant functional ovarian reserve (FOR) at young ages may clinically obfuscate prematurely diminished FOR (PDFOR), we investigated in young oocyte donors genotypes and sub-genotypes of the FMR1 gene, in prior studies associated with specific ovarian aging patterns, and determined whether they already at such young age were associated with variations in ovarian reserve (OR). We also investigated racial as well as FMR1 associations with menarcheal age in these donors.
methodsIn a cohort study we investigated 157 oocyte donor candidates and, based on the 95% CI of AMH, divided them into normal age-specific (AMH greater or equal to 2.1 ng/mL; n = 121) and PDFOR (AMH < 2.1 ng/mL; n = 36). We then assessed associations between numbers of trinucleotide repeat (CGGn) on the FMR1 gene and FOR (based on anti-Müllerian hormone, AMH).
resultsFMR1 did not associate with AMH overall. Amongst 36 donors with PDFOR, 17 (42%) presented with at least one low (CGGn < 26 ) allele. Remaining donors with normal FOR presented with significantly more CGGn greater or equal to 26 (73.6% vs. 26.4%; P = 0.024) and higher AMH (P = 0.012). This finding was mostly the consequence of interaction between FMR1 (CGGn < 26 vs. CGGn greater or equal to 26) and race (P = 0.013), with Asians most responsible (P = 0.009). Menarcheal age was in donors with normal FOR neither associated with race nor with FMR1 status. In donors with PDFOR race was statistically associated with CGGn (P = 0.018), an association primarily based on significantly delayed age of menarche in African donors with CGGn < 26 in comparison to African donors with CGGn greater or equal to 26 (P = 0.019), and Caucasian (P = 0.017) and Asian donors (P = 0.025) with CGGn < 26.
conclusionsCGGn on FMR1 already at young ages affects FOR, but is clinically apparent only in cases of PDFOR. Screening for low FMR1 CGGn < 26 at young age, thus, appears predictive of later PDFOR.
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