Evidence map›Paper›PMID 23948011›Full record

ArticleAmerican journal of public health2013

Socioeconomic status and lung cancer: unraveling the contribution of genetic admixture.

Melinda C Aldrich, Steve Selvin, Margaret R Wrensch, Jennette D Sison, Helen M Hansen, Charles P Quesenberry, Michael F Seldin, Lisa F Barcellos, Patricia A Buffler, John K Wiencke

Open access · greenAbstract read
In one paragraph

Article in American journal of public health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Rethinking immune studies: population-level immune variations and the path forward.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Pooled it
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  9. Racial Disparities in Lung Cancer Survival: The Contribution of Stage, Treatment, and Ancestry.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2018
    Article
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  15. Variation in levels of the lung carcinogen NNAL and its glucuronides in the urine of cigarette smokers from five ethnic groups with differing risks for lung cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015
    Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Melinda C AldrichAt the time of the study, Melinda C. Aldrich was with the Division of Epidemiology, School of Public Health, University of California, Berkeley. Steve Selvin is with the Division of Biostatistics, School of Public Health, University of California, Berkeley. Margaret R. Wrensch, Helen M. Hansen, and John K. Wiencke are with the Department of Neurologic Surgery, University of California, San Francisco. Jennette D. Sison was with the Department of Neurologic Surgery, University of California, San Francisco. Charles P. Quesenberry Jr, is with the Division of Research, Kaiser Permanente, Oakland, CA. Michael F. Seldin is with the Departments of Biological Chemistry and Medicine, University of California, Davis. Lisa F. Barcellos and Patricia A. Buffler are with the Division of Epidemiology, School of Public Health, University of California, Berkeley.
Steve Selvin
Margaret R Wrensch
Jennette D Sison
Helen M Hansen
Charles P Quesenberry
Michael F Seldin
Lisa F Barcellos
Patricia A Buffler
John K Wiencke
Institute of Molecular Medicine · INKaiser Permanente · US

Funding

Environmental and Molecular Epidemiology of Childhood LeukemiaR01ES009137 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 1999 to 2013
$21.1M
BIOMARKERS OF LUNG CANCER SUSCEPTIBILITY IN MINORITIESR01ES006717 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K. · 1994 to 2009
$8.9M
Admixture Mapping Development and Testing in AA SLER01AR050267 · NIAMS · UNIVERSITY OF CALIFORNIA DAVIS · PI SELDIN, MICHAEL F. · 2005 to 2009
$2.4M
MA Admixture Mapping Development &Application to NIDDMR01DK071185 · NIDDK · UNIVERSITY OF CALIFORNIA DAVIS · PI SELDIN, MICHAEL F. · 2005 to 2008
$1.9M
NIAMS NIH HHS R01 AR050267NIAMS NIH HHS R01AR050267NIDDK NIH HHS R01 DK071185NIEHS NIH HHS 2R01ES09137-06NIEHS NIH HHS R01 ES006717NIEHS NIH HHS R01 ES009137NIEHS NIH HHS R01ES06717PHS HHS R01K071185
6 · The paper itself

Abstract

objectivesWe examined the relationship between genetic ancestry, socioeconomic status (SES), and lung cancer among African Americans and Latinos.

methodsWe evaluated SES and genetic ancestry in a Northern California lung cancer case-control study (1998-2003) of African Americans and Latinos. Lung cancer case and control participants were frequency matched on age, gender, and race/ethnicity. We assessed case-control differences in individual admixture proportions using the 2-sample t test and analysis of covariance. Logistic regression models examined associations among genetic ancestry, socioeconomic characteristics, and lung cancer.

resultsDecreased Amerindian ancestry was associated with higher education among Latino control participants and greater African ancestry was associated with decreased education among African lung cancer case participants. Education was associated with lung cancer among both Latinos and African Americans, independent of smoking, ancestry, age, and gender. Genetic ancestry was not associated with lung cancer among African Americans.

conclusionsFindings suggest that socioeconomic factors may have a greater impact than genetic ancestry on lung cancer among African Americans. The genetic heterogeneity and recent dynamic migration and acculturation of Latinos complicate recruitment; thus, epidemiological analyses and findings should be interpreted cautiously.

Indexed as

Black or African AmericanHispanic or LatinoSocial ClassAdultAgedCaliforniaConfidence IntervalsFemaleGenetic Predisposition to DiseaseGenotyping TechniquesHumansLogistic ModelsLung NeoplasmsMaleMiddle AgedOdds Ratio

Identifiers

PMID23948011
PMCPMC3780736
OpenAlexW1975594168

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.