Evidence map›Paper›PMID 23947361›Full record

ReviewImmunological reviews2013

Bugs in the system.

Vineet D Menachery, Ralph S Baric

Open access · bronzeAbstract readReview
In one paragraph

Review in Immunological reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
7.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Mechanisms of Antiviral Immune Evasion of SARS-CoV-2.Journal of molecular biology · 2022
    Review
  3. Article
  4. Review
  5. MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  6. Epigenetic Landscape during Coronavirus Infection.Pathogens (Basel, Switzerland) · 2017
    Article
  7. Review
  8. Review
  9. Article
  10. Immunity to viruses.Immunological reviews · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Vineet D MenacheryDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7435, USA.
Ralph S Baric
University of North Carolina at Chapel Hill · US

Funding

Unlocking Zika Virus Immune Control and Pathogenesis with the Collaborative CrossU19AI100625 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S, HEISE, MARK T · 2012 to 2021
$36.6M
Evaluation of SARS-CoV 2'O Methyltransferase MutantsF32AI102561 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MENACHERY, VINEET D · 2013 to 2015
$132k
NIAID NIH HHS F32 AI102561NIAID NIH HHS F32AI102561NIAID NIH HHS HHSN272200800060CNIAID NIH HHS U19 AI100625NIAID NIH HHS U19AI100625
6 · The paper itself

Abstract

Immunity to respiratory virus infection is governed by complex biological networks that influence disease progression and pathogenesis. Systems biology provides an opportunity to explore and understand these multifaceted interactions based on integration and modeling of multiple biological parameters. In this review, we describe new and refined systems-based approaches used to model, identify, and validate novel targets within complex networks following influenza and coronavirus infection. In addition, we propose avenues for extension and expansion that can revolutionize our understanding of infectious disease processes. Together, we hope to provide a window into the unique and expansive opportunity presented by systems biology to understand complex disease processes within the context of infectious diseases.

Indexed as

Systems BiologyVirologyVirus Physiological PhenomenaAnimalsHost-Pathogen InteractionsHumansTranslational Research, BiomedicalcoronavirusH1N1H5N1influenzaMERS-CoVSARS-CoVsystems biology

Identifiers

PMID23947361
PMCPMC3748621
OpenAlexW2069906928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.