ArticleBeilstein journal of organic chemistry2013
ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans.
Article in Beilstein journal of organic chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- RegioselectiveBeilstein journal of organic chemistry · 2021Article
- Fluconazole conjugated-gold nanorods as an antifungal nanomedicine with low cytotoxicity against human dermal fibroblasts.RSC advances · 2020Article
- Antifungal effects of indolicidin-conjugated gold nanoparticles against fluconazole-resistant strains ofInternational journal of nanomedicine · 2019Article
- Cinnamic Acid Analogs as Intervention Catalysts for Overcoming Antifungal Tolerance.Molecules (Basel, Switzerland) · 2017Article
- Potent Antifungal Synergy of Phthalazinone and Isoquinolones with Azoles AgainstACS medicinal chemistry letters · 2017Article
- Targeting efflux pumps to overcome antifungal drug resistance.Future medicinal chemistry · 2016Review
- Synergistic Effects and Mechanisms of Budesonide in Combination with Fluconazole against Resistant Candida albicans.PloS one · 2016Article
- Augmenting the Activity of Monoterpenoid Phenols against Fungal Pathogens Using 2-Hydroxy-4-methoxybenzaldehyde that Target Cell Wall Integrity.International journal of molecular sciences · 2015Article
- Potent Synergy between Spirocyclic Pyrrolidinoindolinones and Fluconazole against Candida albicans.ChemMedChem · 2015Article
- Quercetin sensitizes fluconazole-resistant candida albicans to induce apoptotic cell death by modulating quorum sensing.Antimicrobial agents and chemotherapy · 2015Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
The National Institutes of Health Molecular Libraries and Probe Production Centers Network (NIH-MLPCN) screened >300,000 compounds to evaluate their ability to restore fluconazole susceptibility in resistant Candida albicans isolates. Additional counter screens were incorporated to remove substances inherently toxic to either mammalian or fungal cells. A substituted indazole possessing the desired bioactivity profile was selected for further development, and initial investigation of structure-activity relationships led to the discovery of ML212.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.