ArticleThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology2013
Effect of Lutein on L-NAME-Induced Hypertensive Rats.
Article in The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- Oral Toxicity Profile of a Novel Silk Lutein Extract and Assessment of Its Cardiovascular Benefits in Rodents.International journal of molecular sciences · 2026Article
- Isosakuranetin ameliorates hypertension in rats induced by L-NAME.Journal of pharmaceutical health care and sciences · 2025Article
- Central nervous system mechanisms of salt-sensitive hypertension.Physiological reviews · 2025Review
- Nanoformulation of valsartan-loaded tablet attenuates L-NAME-induced hypertension: role of Nrf2/PPARγ/AT1 signaling pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Article
- Decreased blood pressure with acute administration of quercetin in L-NAME-induced hypertensive rats.Basic & clinical pharmacology & toxicology · 2025Article
- Soursop leaf extract and fractions protects against L-NAME-induced hypertension and hyperlipidemia.Frontiers in nutrition · 2024Article
- Dietary carotenoids to improve hypertension.Heliyon · 2023Review
- Cinnamon modulates the pharmacodynamic & pharmacokinetic of amlodipine in hypertensive rats.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Pulegone Prevents Hypertension through Activation of Muscarinic Receptors and Cyclooxygenase Pathway in L-NAME-Induced Hypertensive Rats.Cardiovascular therapeutics · 2023Article
- Effects of Riceberry Rice Bran Oil Supplementation on Oxidative Stress and Cardiovascular Risk Biomarkers in Older Adults with Prehypertension.Preventive nutrition and food science · 2022Article
- Changes in Pharmacokinetics and Pharmacodynamics of Losartan in Experimental Diseased Rats Treated withPharmaceuticals (Basel, Switzerland) · 2022Article
- Anti-Hypertensive Activity of Some Selected Unani Formulations: An Evidence-Based Approach for Verification of Traditional Unani Claims Using LC-MS/MS for the Evaluation of Clinically Relevant Blood Parameters in Laboratory Rats.Journal of clinical medicine · 2022Article
- Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension.Pharmaceutical biology · 2021Article
- Lutein as a Modulator of Oxidative Stress-Mediated Inflammatory Diseases.Antioxidants (Basel, Switzerland) · 2021Review
- Serum and Macular Carotenoids in Relation to Retinal Vessel Caliber Fifteen Years Later, in the Second Carotenoids in Age-Related Eye Disease Study.Investigative ophthalmology & visual science · 2021Article
- Article
- Potential pharmacodynamic and pharmacokinetic interactions ofSaudi journal of biological sciences · 2020Article
- Antihypertensive effects of the hydro-ethanol extract of Senecio serratuloides DC in rats.BMC complementary and alternative medicine · 2019Article
- Antihypertensive Effects of Roselle-Olive Combination in L-NAME-Induced Hypertensive Rats.Oxidative medicine and cellular longevity · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the antihypertensive effect of lutein on N(G) -nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats. Daily oral administration of L-NAME (40 mg/kg)-induced a rapid progressive increase in mean arterial pressure (MAP). L-NAME significantly increased MAP from the first week compared to that in the control and reached 193.3±9.6 mmHg at the end of treatment. MAP in the lutein groups was dose-dependently lower than that in the L-NAME group. Similar results were observed for systolic and diastolic blood pressure of L-NAME-induced hypertensive rats. The control group showed little change in heart rate for 3 weeks, whereas L-NAME significantly reduced heart rate from 434±26 to 376±33 beats/min. Lutein (2 mg/kg) significantly prevented the reduced heart rate induced by L-NAME. L-NAME caused hypertrophy of heart and kidney, and increased plasma lipid peroxidation four-fold but significantly reduced plasma nitrite and glutathione concentrations, which were significantly prevented by lutein in a dose-dependent manner. These findings suggest that lutein affords significant antihypertensive and antioxidant effects against L-NAME-induced hypertension in rats.
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