ArticleDevelopment (Cambridge, England)2013
Control of tissue morphology by Fasciclin III-mediated intercellular adhesion.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
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- The molecular landscape of neural differentiation in the developing Drosophila brain revealed by targeted scRNA-seq and multi-informatic analysis.Cell reports · 2021Article
- Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development.Journal of developmental biology · 2021Review
- Transcriptional Correlates of Chronic Alcohol Neuroadaptation inFrontiers in behavioral neuroscience · 2021Article
- Neuronal immunoglobulin superfamily cell adhesion molecules in epithelial morphogenesis: insights fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Physiology, Development, and Disease Modeling in theGenetics · 2020Review
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- Jak-Stat pathway induceseLife · 2018Article
- Cell Chirality Drives Left-Right Asymmetric Morphogenesis.Frontiers in cell and developmental biology · 2018Review
- JAK/STAT signaling is necessary for cell monosis prior to epithelial cell apoptotic extrusion.Cell death & disease · 2017Article
- Alteration of osteoblast arrangement via direct attack by cancer cells: New insights into bone metastasis.Scientific reports · 2017Article
- Septate Junction Proteins Play Essential Roles in Morphogenesis Throughout Embryonic Development in Drosophila.G3 (Bethesda, Md.) · 2016Article
- α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epithelium.Development (Cambridge, England) · 2016Article
- Natural Genetic Variation and Candidate Genes for Morphological Traits in Drosophila melanogaster.PloS one · 2016Article
- RhoGAP68F controls transport of adhesion proteins in Rab4 endosomes to modulate epithelial morphogenesis of Drosophila leg discs.Developmental biology · 2015Article
- JAK-STAT pathway in Drosophila morphogenesis: From organ selector to cell behavior regulator.JAK-STAT · 2013Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Morphogenesis is dependent on the orchestration of multiple developmental processes to generate mature functional organs. However, the signalling pathways that coordinate morphogenesis and the mechanisms that translate these signals into tissue shape changes are not well understood. Here, we demonstrate that changes in intercellular adhesion mediated by the transmembrane protein Fasciclin III (FasIII) represent a key mediator of morphogenesis. Using the embryonic Drosophila hindgut as an in vivo model for organogenesis, we show that the tightening of hindgut curvature that normally occurs between embryonic stage 12 and 15 to generate the characteristic shepherd's crook shape is dependent on localised JAK/STAT pathway activation. This localised pathway activity drives the expression of FasIII leading to its subcellular lateralisation at a stage before formation of septate junctions. Additionally, we show that JAK/STAT- and FasIII-dependent morphogenesis also regulates folds within the third instar wing imaginal disc. We show that FasIII forms homophilic intercellular interactions that promote intercellular adhesion in vivo and in cultured cells. To explore these findings, we have developed a mathematical model of the developing hindgut, based on the differential interfacial tension hypothesis (DITH) linking intercellular adhesion and localised surface tension. Our model suggests that increased intercellular adhesion provided by FasIII can be sufficient to drive the tightening of tube curvature observed. Taken together, these results identify a conserved molecular mechanism that directly links JAK/STAT pathway signalling to intercellular adhesion and that sculpts both tubular and planar epithelial shape.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.