ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Number of spikes in climbing fibers determines the direction of cerebellar learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 66 citations in OpenAlex.
- Focal Task-Specific Dystonia Beyond M1: Network Adaptations and a Causal-Architecture Taxonomy of Dystonia.Brain sciences · 2026Article
- Classical conditioning of Purkinje cell responsesBiochemistry and biophysics reports · 2026Article
- The Effect of Nucleo-Olivary Stimulation on Climbing Fiber EPSPs in Purkinje Cells.Cerebellum (London, England) · 2024Article
- The Cerebellum as an Embodying Machine.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity.Communications biology · 2022Article
- Brain-Inspired Spiking Neural Network Controller for a Neurorobotic Whisker System.Frontiers in neurorobotics · 2022Article
- NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Gating by Functionally Indivisible Cerebellar Circuits: a Hypothesis.Cerebellum (London, England) · 2021Article
- Population coding in the cerebellum: a machine learning perspective.Journal of neurophysiology · 2020Review
- Article
- α2δ-2 Protein Controls Structure and Function at the Cerebellar Climbing Fiber Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Complex spike clusters and false-positive rejection in a cerebellar supervised learning rule.The Journal of physiology · 2019Article
- Complex Spike Wars: a New Hope.Cerebellum (London, England) · 2018Review
- Depressed by Learning-Heterogeneity of the Plasticity Rules at Parallel Fiber Synapses onto Purkinje Cells.Cerebellum (London, England) · 2018Review
- Cerebellar learning using perturbations.eLife · 2018Article
- Article
- Heterogeneity of Purkinje cell simple spike-complex spike interactions: zebrin- and non-zebrin-related variations.The Journal of physiology · 2017Article
- Learned response sequences in cerebellar Purkinje cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Climbing Fibers Control Purkinje Cell Representations of Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Consensus Paper: Towards a Systems-Level View of Cerebellar Function: the Interplay Between Cerebellum, Basal Ganglia, and Cortex.Cerebellum (London, England) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebellar learning requires context information from mossy fibers and a teaching signal through the climbing fibers from the inferior olive. Although the inferior olive fires in bursts, virtually all studies have used a teaching signal consisting of a single pulse. Following a number of failed attempts to induce cerebellar learning in decerebrate ferrets with a nonburst signal, we tested the effect of varying the number of pulses in the climbing fiber teaching signal. The results show that training with a single pulse in a conditioning paradigm in vivo does not result in learning, but rather causes extinction of a previously learned response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.