ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Robust encoding of stimulus identity and concentration in the accessory olfactory system.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Stimulus-Induced Theta-Band LFP Oscillations Format Neuronal Representations of Social Chemosignals in the Mouse Accessory Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The Bruce effect: Representational stability and memory formation in the accessory olfactory bulb of the female mouse.Cell reports · 2022Article
- Do all mice smell the same? Chemosensory cues from inbred and wild mouse strains elicit stereotypic sensory representations in the accessory olfactory bulb.BMC biology · 2021Article
- Competitive binding predicts nonlinear responses of olfactory receptors to complex mixtures.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Odorant mixtures elicit less variable and faster responses than pure odorants.PLoS computational biology · 2018Article
- Temporal Response Properties of Accessory Olfactory Bulb Neurons: Limitations and Opportunities for Decoding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
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- Faecal bile acids are natural ligands of the mouse accessory olfactory system.Nature communications · 2016Article
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- Mammalian pheromones: emerging properties and mechanisms of detection.Current opinion in neurobiology · 2015Review
- Extracting Social Information from Chemosensory Cues: Consideration of Several Scenarios and Their Functional Implications.Frontiers in neuroscience · 2015Article
- Tuning properties and dynamic range of type 1 vomeronasal receptors.Frontiers in neuroscience · 2015Article
- An olfactory cocktail party: figure-ground segregation of odorants in rodents.Nature neuroscience · 2014Article
- Scenting Waldo: analyzing olfactory scenes.Nature neuroscience · 2014Article
- A family of nonclassical class I MHC genes contributes to ultrasensitive chemodetection by mouse vomeronasal sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Reliable sex and strain discrimination in the mouse vomeronasal organ and accessory olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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2 authors.
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Abstract
Sensory systems represent stimulus identity and intensity, but in the neural periphery these two variables are typically intertwined. Moreover, stable detection may be complicated by environmental uncertainty; stimulus properties can differ over time and circumstance in ways that are not necessarily biologically relevant. We explored these issues in the context of the mouse accessory olfactory system, which specializes in detection of chemical social cues and infers myriad aspects of the identity and physiological state of conspecifics from complex mixtures, such as urine. Using mixtures of sulfated steroids, key constituents of urine, we found that spiking responses of individual vomeronasal sensory neurons encode both individual compounds and mixtures in a manner consistent with a simple model of receptor-ligand interactions. Although typical neurons did not accurately encode concentration over a large dynamic range, from population activity it was possible to reliably estimate the log-concentration of pure compounds over several orders of magnitude. For binary mixtures, simple models failed to accurately segment the individual components, largely because of the prevalence of neurons responsive to both components. By accounting for such overlaps during model tuning, we show that, from neuronal firing, one can accurately estimate log-concentration of both components, even when tested across widely varying concentrations. With this foundation, the difference of logarithms, log A - log B = log A/B, provides a natural mechanism to accurately estimate concentration ratios. Thus, we show that a biophysically plausible circuit model can reconstruct concentration ratios from observed neuronal firing, representing a powerful mechanism to separate stimulus identity from absolute concentration.
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