ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Melanocortin signaling in the brainstem influences vagal outflow to the stomach.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Beyond satiety: unraveling the complex roles of POMC neurons in behavior and metabolism.Reviews in endocrine & metabolic disorders · 2026Review
- Glucagon-like Peptide-2 Acts Partially Through Central GLP-2R and MC4R in Mobilizing Stored Lipids from the Intestine.Nutrients · 2025Article
- Peripheral actions and direct central-local communications of melanocortin 4 receptor signaling.Journal of sport and health science · 2023Review
- Interactions between Brainstem Neurons That Regulate the Motility to the Stomach.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Brainstem Neuronal Circuitries Controlling Gastric Tonic and Phasic Contractions: A Review.Cellular and molecular neurobiology · 2022Review
- Brainstem activation of GABAFrontiers in neuroscience · 2022Article
- Central HVeterinary research forum : an international quarterly journal · 2020Article
- The melanocortin pathway and control of appetite-progress and therapeutic implications.The Journal of endocrinology · 2019Review
- GABAFrontiers in neuroscience · 2019Article
- Subdiaphragmatic Vagotomy With Pyloroplasty Ameliorates the Obesity Caused by Genetic Deletion of the Melanocortin 4 Receptor in the Mouse.Frontiers in neuroscience · 2018Article
- The Role of the Melanocortin System in Metabolic Disease: New Developments and Advances.Neuroendocrinology · 2017Review
- Optogenetic and pharmacological evidence that somatostatin-GABA neurons are important regulators of parasympathetic outflow to the stomach.The Journal of physiology · 2016Article
- Activation of Brainstem Pro-opiomelanocortin Neurons Produces Opioidergic Analgesia, Bradycardia and Bradypnoea.PloS one · 2016Article
- Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists.Molecular endocrinology (Baltimore, Md.) · 2015Article
- Melanocortin-4 receptor expression in autonomic circuitry involved in gastric function.International journal of clinical and experimental medicine · 2015Article
- NMDA-type glutamate receptors participate in reduction of food intake following hindbrain melanocortin receptor activation.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo.Cell metabolism · 2014Article
- Participation of the central melanocortin system in metabolic regulation and energy homeostasis.Cellular and molecular life sciences : CMLS · 2014Review
- Central vagal afferent endings mediate reduction of food intake by melanocortin-3/4 receptor agonist.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
Activation of melanocortin 4 receptors (MC4-Rs) in brain nuclei associated with food intake profoundly influences consummatory behavior. Of these nuclei, the dorsal motor vagal nucleus (DMV), which has a dense concentration of MC4-Rs, is an important regulator of gastric tone and motility. Hence, the present study sought to examine the role of MC4-Rs in this nucleus on these activities. Using an in vivo approach, MC4-R agonists, melanotan-II (MT-II) or α-melanocyte stimulating hormone (α-MSH), were unilaterally microinjected into the DMV of rats, and their effects were noted on gastric activity. MT-II decreased phasic contractions, whereas α-MSH increased their amplitude. Both effects were blocked by the MC4-R antagonist SHU9119 or by ipsilateral vagotomy. Microinjection of the agonists (MT-II and α-MSH) into the overlying nucleus of the solitary tract (NTS), an important component of "vago-vagal" gastric circuitry, decreased phasic contractions. In addition, α-MSH reduced gastric tone and mean arterial blood pressure. To study the underlying mechanisms of the effect of MC4-R stimulation on gastric activity, electrophysiological recordings were made from labeled DMV antrum neurons in rat pups and MC4-R(-/-) mice. Bath application of MT-II or α-MSH significantly reduced spontaneous action potentials (but not in MC4-R(-/-) mice). However, in low-calcium ACSF, MT-II decreased neuronal firing, whereas α-MSH increased it. These effects mirror those of our in vivo DMV studies. Altogether, our novel findings show that activation of MC4-Rs in the brainstem, particularly in the medial NTS by the endogenous peptide α-MSH, modulates gastric activity, which may have physiological relevance for food intake and gastric function.
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Registered trials
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