ArticlePlant physiology2013
Arabidopsis tetraspanins are confined to discrete expression domains and cell types in reproductive tissues and form homo- and heterodimers when expressed in yeast.
Article in Plant physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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55 citing papers in PubMed, 86 citations in OpenAlex.
- Functional insights into dispensable genes using genome-wide loss-of-function burden tests in Arabidopsis.The Plant cell · 2026Article
- Molecular insights into the production of extracellular vesicles by plants.Plant physiology · 2026Article
- AFrontiers in plant science · 2026Article
- Tetraspanin OsTET8 acts as a negative regulator of root development in rice.Rice (New York, N.Y.) · 2025Article
- Proteomic snapshot of pattern triggered immunity in the Arabidopsis leaf apoplast.The Plant journal : for cell and molecular biology · 2025Article
- Kinesins control male germ unit assembly for sperm delivery in Arabidopsis.Nature plants · 2025Article
- Kinesin proteins HUG1 and HUG2 are essential for the formation and transportation of male germ units in Arabidopsis pollen tubes.Nature plants · 2025Article
- Arabidopsis Produces Distinct Subpopulations of Extracellular Vesicles That Respond Differentially to Biotic Stress, Altering Growth and Infectivity of a Fungal Pathogen.Journal of extracellular vesicles · 2025Article
- Multifaceted Therapeutic Potential of Plant-Derived Exosomes: Immunomodulation, Anticancer, Anti-Aging, Anti-Melanogenesis, Detoxification, and Drug Delivery.Biomolecules · 2025Review
- Plant-derived nanovesicles: Promising therapeutics and drug delivery nanoplatforms for brain disorders.Fundamental research · 2025Review
- DUO1 Activated Zinc Finger (AtDAZ) protein role in the generative cell body morphogenesis.Plant molecular biology · 2025Article
- Tetraspanin 5 orchestrates resilience to salt stress through the regulation of ion and reactive oxygen species homeostasis in rice.Plant biotechnology journal · 2025Article
- Exosomes in Disease Therapy: Plant-Derived Exosome-Like Nanoparticles Current Status, Challenges, and Future Prospects.International journal of nanomedicine · 2025Review
- Identification of the tetraspanin gene family in sugarcane and its response to sugarcane mosaic virus infection.Frontiers in plant science · 2025Article
- Extracellular vesicles isolated from Arabidopsis thaliana leaves reveal characteristics of mammalian exosomes.Protoplasma · 2024Article
- Arabidopsis apoplast TET8 positively correlates to leaf senescence, andPlant direct · 2024Article
- Nano-Silicon Triggers Rapid Transcriptomic Reprogramming and Biochemical Defenses inJournal of fungi (Basel, Switzerland) · 2023Article
- Genetic control of generative cell shape by DUO1 in Arabidopsis.Plant reproduction · 2023Article
- Behavior of Male Gamete Fusogen GCS1/HAP2 and the Regulation inBiomolecules · 2023Article
- TETRASPANIN 8-1 fromFrontiers in plant science · 2023Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tetraspanins are evolutionary conserved transmembrane proteins present in all multicellular organisms. In animals, they are known to act as central organizers of membrane complexes and thought to facilitate diverse biological processes, such as cell proliferation, movement, adhesion, and fusion. The genome of Arabidopsis (Arabidopsis thaliana) encodes 17 members of the tetraspanin family; however, little is known about their functions in plant development. Here, we analyzed their phylogeny, protein topology, and domain structure and surveyed their expression and localization patterns in reproductive tissues. We show that, despite their low sequence identity with metazoan tetraspanins, plant tetraspanins display the typical structural topology and most signature features of tetraspanins in other multicellular organisms. Arabidopsis tetraspanins are expressed in diverse tissue domains or cell types in reproductive tissues, and some accumulate at the highest levels in response to pollination in the transmitting tract and stigma, male and female gametophytes and gametes. Arabidopsis tetraspanins are preferentially targeted to the plasma membrane, and they variously associate with specialized membrane domains, in a polarized fashion, to intercellular contacts or plasmodesmata. A membrane-based yeast (Saccharomyces cerevisiae) two-hybrid system established that tetraspanins can physically interact, forming homo- and heterodimer complexes. These results, together with a likely genetic redundancy, suggest that, similar to their metazoan counterparts, plant tetraspanins might be involved in facilitating intercellular communication, whose functions might be determined by the composition of tetraspanin complexes and their binding partners at the cell surface of specific cell types.
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