ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2013
The importance of long-term acute care hospitals in the regional epidemiology of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 2 of them syntheses that pooled it.
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117 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Control of Carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa in Healthcare Facilities: A Systematic Review and Reanalysis of Quasi-experimental Studies.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Pooled it
- A Systematic Review and Meta-analyses of the Clinical Epidemiology of Carbapenem-Resistant Enterobacteriaceae.Antimicrobial agents and chemotherapy · 2018Pooled it
- Dissemination ofEmerging microbes & infections · 2026Article
- Genomic inference of sites of transmission during regional spread of blaNature communications · 2026Article
- A public health risk model using prior healthcare exposures identifies healthcare-associated pathogen carriage.Infection control and hospital epidemiology · 2026Article
- Projected impact of a pathogen reduction intervention on carbapenem-resistant Enterobacterales bloodstream infections and deaths in the United States.Infection control and hospital epidemiology · 2026Article
- Regression-based modeling of pairwise genomic linkage data identifies risk factors for healthcare-associated pathogen transmission: application to carbapenem-resistantMicrobiology spectrum · 2026Article
- Detection and distribution of carbapenemase-encoding genes in clinicalIranian journal of microbiology · 2026Article
- Characteristics of Carbapenem-ResistantPublic health weekly report · 2026Article
- Phylogenetic Context of Antibiotic Resistance Provides Insights into the Dynamics of Resistance Emergence and Spread.The Journal of infectious diseases · 2025Article
- Transmission thresholds for the spread of infections in healthcare facilities.PLoS computational biology · 2025Article
- Identifying drivers of β-lactam/β-lactamase inhibitor resistance emergence and spread before their clinical deployment.medRxiv : the preprint server for health sciences · 2025Article
- Clinical evaluation of advanced MALDI-TOF MS for carbapenemase subtyping in Gram-negative isolates.Journal of clinical microbiology · 2025Article
- Clinical outcomes and the impact of treatment modalities in children with carbapenem-resistant Enterobacteriaceae bloodstream infections: a retrospective cohort study from a tertiary university hospital.The Journal of antimicrobial chemotherapy · 2025Article
- Identifying risk factors for carbapenem-resistant Acinetobacter baumannii carriage upon admission: a case-case control study.Antimicrobial resistance and infection control · 2024Article
- Susceptibility of various Gram-negative bacteria to antibacterial agents: SMART in China 2019-2020.BMC microbiology · 2024Article
- Relationship between chlorhexidine gluconate concentration and microbial colonization of patients' skin.Infection control and hospital epidemiology · 2024Article
- A multi-center validation of the electronic health record admission source and discharge location fields against the clinical notes for identifying inpatients with long-term care facility exposure.Infection control and hospital epidemiology · 2024Article
- Regional impact of multidrug-resistant organism prevention bundles implemented by facility type: A modeling study.Infection control and hospital epidemiology · 2024Article
- Concurrent transmission of multiple carbapenemases in a long-term acute-care hospital.Infection control and hospital epidemiology · 2024Review
57 more citing papers are in PubMed but not listed here.
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Funding
Abstract
backgroundIn the United States, Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae are increasingly detected in clinical infections; however, the colonization burden of these organisms among short-stay and long-term acute care hospitals is unknown.
methodsShort-stay acute care hospitals with adult intensive care units (ICUs) in the city of Chicago were recruited for 2 cross-sectional single-day point prevalence surveys (survey 1, July 2010-January 2011; survey 2, January-July 2011). In addition, all long-term acute care hospitals (LTACHs) in the Chicago region (Cook County) were recruited for a single-day point prevalence survey during January-May 2011. Swab specimens were collected from rectal, inguinal, or urine sites and tested for Enterobacteriaceae carrying blaKPC.
resultsWe surveyed 24 of 25 eligible short-stay acute care hospitals and 7 of 7 eligible LTACHs. Among LTACHs, 30.4% (119 of 391) of patients were colonized with KPC-producing Enterobacteriaceae, compared to 3.3% (30 of 910) of short-stay hospital ICU patients (prevalence ratio, 9.2; 95% confidence interval, 6.3-13.5). All surveyed LTACHs had patients harboring KPC (prevalence range, 10%-54%), versus 15 of 24 short-stay hospitals (prevalence range, 0%-29%). Several patient-level covariates present at the time of survey-LTACH facility type, mechanical ventilation, and length of stay-were independent risk factors for KPC-producing Enterobacteriaceae colonization.
conclusionsWe identified high colonization prevalence of KPC-producing Enterobacteriaceae among patients in LTACHs. Patients with chronic medical care needs in long-term care facilities may play an important role in the spread of these extremely drug-resistant pathogens.
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