ArticleAngewandte Chemie (International ed. in English)2013
LEGO-NMR spectroscopy: a method to visualize individual subunits in large heteromeric complexes.
Article in Angewandte Chemie (International ed. in English), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Subunit-specific isotope labelling of heteromeric complexes using cell-free protein expression: application to the 760 kDa ClpXP molecular machine.RSC chemical biology · 2026Article
- NMR in the Age of Modern Biomedical Research and Drug Discovery.Journal of molecular biology · 2025Review
- Differentially labeled flaviviral protease-cofactor complex for NMR spectroscopic applications.Protein expression and purification · 2025Article
- Monitoring conformational changes in the human neurotransmitter transporter homologue LeuT withJournal of neurochemistry · 2025Article
- Insights into the association of the Chlamydia trachomatis type III secretion chaperone complex, Scc4:Scc1, from sequential expression in Escherichia coli.Protein expression and purification · 2024Article
- HIV-1 VIF and human APOBEC3G interaction directly observed through molecular specific labeling using a new dual promotor vector.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2022Article
- Current NMR Techniques for Structure-Based Drug Discovery.Molecules (Basel, Switzerland) · 2018Review
- M3: an integrative framework for structure determination of molecular machines.Nature methods · 2017Article
- Determination of ligand binding modes in weak protein-ligand complexes using sparse NMR data.Journal of biomolecular NMR · 2016Article
- The oligomeric architecture of the archaeal exosome is important for processive and efficient RNA degradation.Nucleic acids research · 2016Article
- NMR approaches in structure-based lead discovery: recent developments and new frontiers for targeting multi-protein complexes.Progress in biophysics and molecular biologyReview
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4 authors.
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Abstract
Seeing the big picture: Asymmetric macromolecular complexes that are NMR active in only a subset of their subunits can be prepared, thus decreasing NMR spectral complexity. For the hetero heptameric LSm1-7 and LSm2-8 rings NMR spectra of the individual subunits of the complete complex are obtained, showing a conserved RNA binding site. This LEGO-NMR technique makes large asymmetric complexes accessible to detailed NMR spectroscopic studies.
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