ArticleHuman brain mapping2014
A study of cortical morphology in children with fetal alcohol spectrum disorders.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prenatal alcohol exposure and associations with physical size, dysmorphology and neurodevelopment: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- Infant circulating MicroRNAs as biomarkers of effect in fetal alcohol spectrum disorders.Scientific reports · 2021Trial
- Impact of Prenatal Alcohol Exposure on Cerebral Cortex Development.Advances in experimental medicine and biology · 2026Review
- Regional hippocampal thinning and gyrification abnormalities and associated cognition in children with prenatal alcohol exposure.Journal of neurodevelopmental disorders · 2025Article
- Article
- Brain morphometry and chronic inflammation in Bangladeshi children growing up in extreme poverty.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Fetal alcohol spectrum disorders.Nature reviews. Disease primers · 2023Review
- Mapping corpus callosum surface reduction in fetal alcohol spectrum disorders with sulci and connectivity-based parcellation.Frontiers in neuroscience · 2023Article
- The impact of prenatal alcohol and/or tobacco exposure on brain structure in a large sample of children from a South African birth cohort.Alcoholism, clinical and experimental research · 2022Article
- The impact of prenatal alcohol exposure on gray matter volume and cortical surface area of 2 to 3-year-old children in a South African birth cohort.Alcoholism, clinical and experimental research · 2022Article
- Stability and change in the interpretation of facial emotions in fetal alcohol spectrum disorders from childhood to adolescence.Alcoholism, clinical and experimental research · 2022Article
- Distinctive neural correlates of phonological and reading impairment in fetal alcohol-exposed adolescents with and without facial dysmorphology.Neuropsychologia · 2022Article
- Evaluation of Brain Alterations and Behavior in Children With Low Levels of Prenatal Alcohol Exposure.JAMA network open · 2022Article
- Reading impairment in adolescents with fetal alcohol spectrum disorders.Scientific studies of reading : the official journal of the Society for the Scientific Study of Reading · 2022Article
- Cortical gyrification in children with attention deficit-hyperactivity disorder and prenatal alcohol exposure.Drug and alcohol dependence · 2021Article
- Ethanol Gestational Exposure Impairs Vascular Development and Endothelial Potential to Control BBB-Associated Astrocyte Function in the Developing Cerebral Cortex.Molecular neurobiology · 2021Article
- Towards Deciphering the Fetal Foundation of Normal Cognition and Cognitive Symptoms From Sulcation of the Cortex.Frontiers in neuroanatomy · 2021Article
- Reduced Hippocampal Volumes Partially Mediate Effects of Prenatal Alcohol Exposure on Spatial Navigation on a Virtual Water Maze Task in Children.Alcoholism, clinical and experimental research · 2020Article
- Gender Differences in the Outcome of Offspring Prenatally Exposed to Drugs of Abuse.Frontiers in behavioral neuroscience · 2020Review
- Validity of automated FreeSurfer segmentation compared to manual tracing in detecting prenatal alcohol exposure-related subcortical and corpus callosal alterations in 9- to 11-year-old children.NeuroImage. Clinical · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Prenatal alcohol exposure is responsible for a broad range of brain structural malformations, which can be studied using magnetic resonance imaging (MRI). Advanced MRI methods have emerged to characterize brain abnormalities, but the teratogenic effects of alcohol on cortical morphology have received little attention to date. Twenty-four 9-year-old children with fetal alcohol spectrum disorders (9 with fetal alcohol syndrome, 15 heavy exposed nonsyndromal children) and 16 age-matched controls were studied to assess the effect of alcohol consumption during pregnancy on cortical morphology. An automated method was applied to 3D T1-weighted images to assess cortical gyrification using global and regional sulcal indices and two region-based morphological measurements, mean sulcal depth and fold opening. Increasing levels of alcohol exposure were related to reduced cortical folding complexity, even among children with normal brain size, indicating a reduction of buried cortical surface. Fold opening was the strongest anatomical correlate of prenatal alcohol intake, indicating a widening of sulci in all regions that were examined. These data identify cortical morphology as a suitable marker for further investigation of brain damage associated with prenatal alcohol exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.