Evidence map›Paper›PMID 23946100›Full record

ArticleProteins2014

Assessment of protein disorder region predictions in CASP10.

Bohdan Monastyrskyy, Andriy Kryshtafovych, John Moult, Anna Tramontano, Krzysztof Fidelis

Open access · bronzeAbstract read
In one paragraph

Article in Proteins, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 164 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Evaluation of predictions of disordered binding regions in the CAID2 experiment.Computational and structural biotechnology journal · 2025
    Review
  5. Prediction of Disordered Linear Interacting Peptides with CLIP.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  6. Accurate and Fast Prediction of Intrinsic Disorder Using flDPnn.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Computational prediction of disordered binding regions.Computational and structural biotechnology journal · 2023
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Predicting Protein Conformational Disorder and Disordered Binding Sites.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  18. Deep learning in prediction of intrinsic disorder in proteins.Computational and structural biotechnology journal · 2022
    Review
  19. Article
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Bohdan MonastyrskyyGenome Center University of California, Davis, Davis, California, 95616.
Andriy Kryshtafovych
John Moult
Anna Tramontano
Krzysztof Fidelis
University of California, Davis · USAdvanced Bioscience Laboratories (United States) · USSapienza University of Rome · IT

Funding

The Protein Structure Inittiative KnowledgebaseU01GM093324 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI BERMAN, HELEN M · 2010 to 2015
$12.9M
Prospective analysis to determine model accuracy performance and boundaries in the post-AlphaFold2 environmentR01GM100482 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIDELIS, KRZYSZTOF A · 2012 to 2025
$11.1M
NIGMS NIH HHS R01 GM100482NIGMS NIH HHS U01 GM093324NIGMS NIH HHS U01GM093324-01
6 · The paper itself

Abstract

The article presents the assessment of disorder region predictions submitted to CASP10. The evaluation is based on the three measures tested in previous CASPs: (i) balanced accuracy, (ii) the Matthews correlation coefficient for the binary predictions, and (iii) the area under the curve in the receiver operating characteristic (ROC) analysis of predictions using probability annotation. We also performed new analyses such as comparison of the submitted predictions with those obtained with a Naïve disorder prediction method and with predictions from the disorder prediction databases D2P2 and MobiDB. On average, the methods participating in CASP10 demonstrated slightly better performance than those in CASP9.

Indexed as

Models, MolecularProtein ConformationComputational BiologyDatabases, ProteinIntrinsically Disordered ProteinsModels, StatisticalIntrinsically Disordered Proteinsassessment of disorder predictionCASPintrinsically disordered proteinsprediction of disordered regionsunstructured proteins

Identifiers

PMID23946100
PMCPMC4406047
OpenAlexW1554017431

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.