Trial reportJAMA psychiatry2013
Impact of cognitive behavioral therapy for social anxiety disorder on the neural dynamics of cognitive reappraisal of negative self-beliefs: randomized clinical trial.
Trial report in JAMA psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00380731 (fMRI of Emotional Reactivity Cognitive Regulation and CBT for Social Phobia), which is not on this map. Cited by 78 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
fMRI of Emotional Reactivity Cognitive Regulation and CBT for Social Phobia
Who cites it
78 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the neural bases of psychotherapy for anxiety and related disorders.Dialogues in clinical neuroscience · 2015Pooled it
- Effects of a 4-week combined breathing control and self-talk intervention on neural activity and coping skills in athletes: a randomized control trial.BMC psychology · 2026Trial
- Neural Responses to Auditory Food Stimuli Following Cognitive Behavioral Therapy for Binge-Eating Disorder.The International journal of eating disorders · 2024Trial
- Serotonin and dopamine transporter availability in social anxiety disorder after combined treatment with escitalopram and cognitive-behavioral therapy.Translational psychiatry · 2022Trial
- Changes in neural reward processing following Amplification of Positivity treatment for depression and anxiety: Preliminary findings from a randomized waitlist controlled trial.Behaviour research and therapy · 2021Trial
- Self-referential processing during observation of a speech performance task in social anxiety disorder from pre- to post-treatment: Evidence of disrupted neural activation.Psychiatry research. Neuroimaging · 2019Trial
- Mechanisms of cognitive-behavioral therapy for obsessive-compulsive disorder involve robust and extensive increases in brain network connectivity.Translational psychiatry · 2017Trial
- Treatment for social anxiety disorder alters functional connectivity in emotion regulation neural circuitry.Psychiatry research. Neuroimaging · 2017Trial
- Neuroplasticity in response to cognitive behavior therapy for social anxiety disorder.Translational psychiatry · 2016Trial
- The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients.Molecular pain · 2015Trial
- Impact of cognitive-behavioral therapy for social anxiety disorder on the neural bases of emotional reactivity to and regulation of social evaluation.Behaviour research and therapy · 2014Trial
- Modulation of resting-state amygdala-frontal functional connectivity by oxytocin in generalized social anxiety disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Self-efficacy effects in combined CBT-attention training for pediatric anxiety.Journal of mood and anxiety disorders · 2026Article
- Social anxiety is associated with greater autonomic and visuocortical generalization of conditioned aversive responses to faces.Cognitive, affective & behavioral neuroscience · 2026Article
- Examining the Mediation Role of Emotion Regulation and Hope in the Impact of COVID-19 on Psychological Well-Being and Mental Health.International journal of psychology : Journal international de psychologie · 2026Article
- An fMRI-informed EEG model of the amygdala is associated with salience network dynamics during naturalistic emotional stimulation.Molecular psychiatry · 2026Article
- Positive Side-Effects of Psychotherapy: The Influence of Cognitive-Behavioral Therapy on Self-Concept in Patients With Panic Disorder.Journal of clinical psychology · 2026Article
- Network analysis of emotion regulation and moral injury symptoms among medical staff.Scientific reports · 2026Article
- Fronto-parietal oscillatory dynamics of emotion regulation as a function of adult attachment orientations.Frontiers in human neuroscience · 2026Article
- Social stress task with parental support or self-instruction decreases negative cognitions in children with social anxiety disorder.Scientific reports · 2025Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
importanceCognitive behavioral therapy (CBT) for social anxiety disorder (SAD) is thought to enhance cognitive reappraisal in patients with SAD. Such improvements should be evident in cognitive reappraisal-related prefrontal cortex responses.
objectiveTo determine whether CBT for SAD modifies cognitive reappraisal-related prefrontal cortex neural signal magnitude and timing when implementing cognitive reappraisal with negative self-beliefs. DESIGN Randomized clinical trial of CBT for SAD vs wait-list control group during a study that enrolled patients from 2007 to 2010.
settingUniversity psychology department.
participantsSeventy-five patients with generalized SAD randomly assigned to CBT or wait list.
interventionSixteen sessions of individual CBT for SAD.
main outcome measuresNegative emotion ratings and functional magnetic resonance imaging blood oxygen-level dependent signal when reacting to and cognitively reappraising negative self-beliefs embedded in autobiographical social anxiety situations. RESULTS During reactivity trials, compared with wait list, CBT produced (1) greater reduction in negative emotion ratings and (2) greater blood oxygen-level dependent signal magnitude in the medial prefrontal cortex. During cognitive reappraisal trials, compared with wait list, CBT produced (3) greater reduction in negative emotion ratings, (4) greater blood oxygen level-dependent signal magnitude in the dorsolateral and dorsomedial prefrontal cortex, (5) earlier temporal onset of dorsomedial prefrontal cortex activity, and (6) greater dorsomedial prefrontal cortex-amygdala inverse functional connectivity. CONCLUSIONS AND RELEVANCE: Modulation of cognitive reappraisal-related brain responses, timing, and functional connectivity may be important brain changes that contribute to the effectiveness of CBT for social anxiety. This study demonstrates that clinically applied neuroscience investigations can elucidate neurobiological mechanisms of change in psychiatric conditions.
trial registrationclinicaltrials.gov Identifier: NCT00380731.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.