ArticleNucleic acids research2013
Distinct isoforms of the Drosophila Brd4 homologue are present at enhancers, promoters and insulator sites.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Decoding the molecular logic of rapidly evolving ZAD zinc finger proteins inScience advances · 2026Article
- A bioinformatics screen reveals hox and chromatin remodeling factors at the Drosophila histone locus.BMC genomic data · 2023Article
- Stepwise modifications of transcriptional hubs link pioneer factor activity to a burst of transcription.Nature communications · 2023Article
- A bioinformatics screen reveals Hox and chromatin remodeling factors at thebioRxiv : the preprint server for biology · 2023Article
- BRD2 compartmentalizes the accessible genome.Nature genetics · 2022Article
- Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent.Nature communications · 2019Article
- BET-ting on Nrf2: How Nrf2 Signaling can Influence the Therapeutic Activities of BET Protein Inhibitors.BioEssays : news and reviews in molecular, cellular and developmental biology · 2018Review
- TAD-free analysis of architectural proteins and insulators.Nucleic acids research · 2018Article
- Polycomb and Trithorax Group Genes inGenetics · 2017Review
- Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function.Molecular cell · 2017Article
- Uncovering direct and indirect molecular determinants of chromatin loops using a computational integrative approach.PLoS computational biology · 2017Article
- The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries.Molecular cell · 2017Article
- Different enhancer classes in Drosophila bind distinct architectural proteins and mediate unique chromatin interactions and 3D architecture.Nucleic acids research · 2017Article
- Compensatory RNA polymerase 2 loading determines the efficacy and transcriptional selectivity of JQ1 in Myc-driven tumors.Leukemia · 2017Article
- The GAGA factor regulatory network: Identification of GAGA factor associated proteins.PloS one · 2017Article
- Chromatin architecture underpinning transcription elongation.Nucleus (Austin, Tex.) · 2016Review
- Review
- Computational Identification of Genomic Features That Influence 3D Chromatin Domain Formation.PLoS computational biology · 2016Article
- Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein.PLoS genetics · 2016Article
- Architectural proteins, transcription, and the three-dimensional organization of the genome.FEBS letters · 2015Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Brd4 is a double bromodomain protein that has been shown to interact with acetylated histones to regulate transcription by recruiting Positive Transcription Elongation Factor b to the promoter region. Brd4 is also involved in gene bookmarking during mitosis and is a therapeutic target for the treatment of acute myeloid leukemia. The Drosophila melanogaster Brd4 homologue is called Fs(1)h and, like its vertebrate counterpart, encodes different isoforms. We have used ChIP-seq to examine the genome-wide distribution of Fs(1)h isoforms. We are able to distinguish the Fs(1)h-L and Fs(1)h-S binding profiles and discriminate between the genomic locations of the two isoforms. Fs(1)h-S is present at enhancers and promoters and its amount parallels transcription levels. Correlations between the distribution of Fs(1)h-S and various forms of acetylated histones H3 and H4 suggest a preference for binding to H3K9acS10ph. Surprisingly, Fs(1)h-L is located at sites in the genome where multiple insulator proteins are also present. The results suggest that Fs(1)h-S may be responsible for the classical role assigned to this protein, whereas Fs(1)h-L may have a new and unexpected role in chromatin architecture by working in conjunction with insulator proteins to mediate intra- or inter-chromosome interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.