ArticleNature communications2013
Axonal and subcellular labelling using modified rabies viral vectors.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- The Application of HSV-1 in Investigating Neurological Diseases.Methods in molecular biology (Clifton, N.J.) · 2025Article
- New rabies viral resources for multi-scale neural circuit mapping.Molecular psychiatry · 2024Article
- Article
- Layer 1 of somatosensory cortex: an important site for input to a tiny cortical compartment.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Article
- HSV-1 H129-Derived Anterograde Neural Circuit Tracers: Improvements, Production, and Applications.Neuroscience bulletin · 2021Article
- Monosynaptic Projections to Excitatory and Inhibitory preBötzinger Complex Neurons.Frontiers in neuroanatomy · 2020Article
- Retrograde monosynaptic tracing through an engineered human embryonic stem cell line reveals synaptic inputs from host neurons to grafted cells.Cell regeneration (London, England) · 2019Article
- Structural Neural Connectivity Analysis in Zebrafish With Restricted Anterograde Transneuronal Viral Labeling and Quantitative Brain Mapping.Frontiers in neural circuits · 2019Article
- Nontoxic, double-deletion-mutant rabies viral vectors for retrograde targeting of projection neurons.Nature neuroscience · 2018Article
- Studies of cortical connectivity using optical circuit mapping methods.The Journal of physiology · 2018Review
- Virus stamping for targeted single-cell infection in vitro and in vivo.Nature biotechnology · 2018Article
- Pedunculopontine glutamatergic neurons control spike patterning in substantia nigra dopaminergic neurons.eLife · 2017Article
- Pseudo-typed Semliki Forest virus delivers EGFP into neurons.Journal of neurovirology · 2017Article
- Shining Light on the Sprout of Life: Optogenetics Applications in Stem Cell Research and Therapy.The Journal of membrane biology · 2016Review
- Vesicular stomatitis virus enables gene transfer and transsynaptic tracing in a wide range of organisms.The Journal of comparative neurology · 2015Article
- Reverse genetics of Mononegavirales: How they work, new vaccines, and new cancer therapeutics.Virology · 2015Review
- An anterograde rabies virus vector for high-resolution large-scale reconstruction of 3D neuron morphology.Brain structure & function · 2015Article
- Neuroanatomy goes viral!Frontiers in neuroanatomy · 2015Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
An important aspect of any neural circuit is the placement of its output synapses, at levels ranging from macroscopic to subcellular. The many new molecular tools for locating and manipulating synapses are limited by the viral vectors available for delivering them. Adeno-associated viruses are the best current means of labelling and manipulating axons and synapses, but they have never expressed more than one transgene highly enough to label fine axonal structure while also labelling or perturbing synapses. Their slow expression also makes them incompatible with retrograde and transsynaptic vectors, preventing powerful combinatorial experiments. Here we show that deletion-mutant rabies virus can be specifically targeted to cells local to an injection site, brightly labelling axons even when coexpressing two other transgenes. We demonstrate several novel capabilities: simultaneously labelling axons and presynaptic terminals, labelling both dendrites and postsynaptic densities, and simultaneously labelling a region's inputs and outputs using co-injected vectors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.