Trial reportThe American journal of clinical nutrition2013
Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial.
Trial report in The American journal of clinical nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01860547 (The Effect of the Bioactives of Sea Buckthorn and Bilberry on the Risk of Metabolic Diseases), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of the Bioactives of Sea Buckthorn and Bilberry on the Risk of Metabolic Diseases
Who cites it
16 citing papers in PubMed.
- Sea Buckthorn in Cardiovascular and Metabolic Health: Evidence for the Role of the Leaves.Nutrients · 2026Review
- Research progress of sea buckthorn (Frontiers in cardiovascular medicine · 2024Review
- Phytochemistry and pharmacology of sea buckthorn (Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2023Review
- Dietary Supplementation with Sea Buckthorn Berry Puree Alters Plasma Metabolomic Profile and Gut Microbiota Composition in Hypercholesterolemia Population.Foods (Basel, Switzerland) · 2022Article
- Anti-Hyperglycemic Effects of Oils and Extracts Derived from Sea Buckthorn - A Comprehensive Analysis Utilizing In Vitro and In Vivo Models.Molecular nutrition & food research · 2022Article
- Metabolomic Profiling Reveals Protective Effects and Mechanisms of Sea Buckthorn Sterol against Carbon Tetrachloride-Induced Acute Liver Injury in Rats.Molecules (Basel, Switzerland) · 2022Article
- Grape polyphenols decrease circulating branched chain amino acids in overfed adults.Frontiers in nutrition · 2022Article
- Potential antiviral activity of isorhamnetin against SARS-CoV-2 spike pseudotyped virus in vitro.Drug development research · 2021Article
- A Scoping Review of the Application of Metabolomics in Nutrition Research: The Literature Survey 2000-2019.Nutrients · 2021Article
- Effects of Bilberry Supplementation on Metabolic and Cardiovascular Disease Risk.Molecules (Basel, Switzerland) · 2020Review
- Fruit Seeds as Sources of Bioactive Compounds: Sustainable Production of High Value-Added Ingredients from By-Products within Circular Economy.Molecules (Basel, Switzerland) · 2019Review
- The impact of sea buckthorn oil fatty acids on human health.Lipids in health and disease · 2019Review
- Optimization of the Steam Explosion Pretreatment Effect on Total Flavonoids Content and Antioxidative Activity of Seabuckthom Pomace by Response Surface Methodology.Molecules (Basel, Switzerland) · 2018Article
- Fruits for Prevention and Treatment of Cardiovascular Diseases.Nutrients · 2017Review
- Metabolic profiling-multitude of technologies with great research potential, but (when) will translation emerge?International journal of epidemiology · 2016Article
- An Investigation into the Antiobesity Effects of Morinda citrifolia L. Leaf Extract in High Fat Diet Induced Obese Rats Using a (1)H NMR Metabolomics Approach.Journal of diabetes research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundBerries are associated with health benefits. Little is known about the effect of baseline metabolome on the overall metabolic responses to berry intake.
objectiveWe studied the effects of berries on serum metabolome.
designEighty overweight women completed this randomized crossover study. During the interventions of 30 d, subjects consumed dried sea buckthorn berries (SBs), sea buckthorn oil (SBo), sea buckthorn phenolics ethanol extract mixed with maltodextrin (SBe+MD) (1:1), or frozen bilberries. Metabolic profiles were quantified from serum samples by using (1)H nuclear magnetic resonance spectroscopy.
resultsAll interventions induced a significant (P < 0.001-0.003) effect on the overall metabolic profiles. The effect was observed both in participants who had a metabolic profile that reflected higher cardiometabolic risk at baseline (group B: P = 0.001-0.008) and in participants who had a lower-risk profile (group A: P < 0.001-0.009). Although most of the changes in individual metabolites were not statistically significant after correction for multiplicity, clear trends were observed. SB-induced effects were mainly on serum triglycerides and very-low-density lipoprotein (VLDL) and its subclasses, which decreased in metabolic group B. SBo induced a decreasing trend in serum total, intermediate-density lipoprotein (IDL), and low-density lipoprotein (LDL) cholesterol and subfractions of IDL and LDL in group B. During the SBe+MD treatment, VLDL fractions and serum triglycerides increased. Bilberries caused beneficial changes in serum lipids and lipoproteins in group B, whereas the opposite was true in group A.
conclusionBerry intake has overall metabolic effects, which depend on the cardiometabolic risk profile at baseline. This trial was registered at clinicaltrials.gov as NCT01860547.
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