Trial reportAnnals of plastic surgery2013
A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery.
Trial report in Annals of plastic surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Comparative assessment of healthy tissue oxygenation using near-infrared imaging, transcutaneous oxygen measurement, and plethysmography.Scientific reports · 2025Trial
- Speckle-illumination spatial frequency domain imaging with a stereo laparoscope for profile-corrected optical property mapping.Journal of biomedical optics · 2025Article
- Flap Monitoring Techniques: A Review.Journal of clinical medicine · 2024Review
- Investigation on the influence of the skin tone on hyperspectral imaging for free flap surgery.Scientific reports · 2024Article
- Quantification of bowel ischaemia using real-time multispectral Single Snapshot Imaging of Optical Properties (SSOP).Surgical endoscopy · 2023Article
- Quantitative spatial mapping of tissue water and lipid content using spatial frequency domain imaging in the 900- to 1000-nm wavelength region.Journal of biomedical optics · 2022Article
- Wavelength and frequency optimization in spatial frequency domain imaging for two-layer tissue.Biomedical optics express · 2022Article
- The application of SFDI and LSI system to evaluate the blood perfusion in skin flap mouse model.Lasers in medical science · 2022Article
- Modeling and Synthesis of Breast Cancer Optical Property Signatures With Generative Models.IEEE transactions on medical imaging · 2021Article
- Speckle illumination SFDI for projector-free optical property mapping.Optics letters · 2021Article
- Direct mapping from diffuse reflectance to chromophore concentrations in multi-Biomedical optics express · 2021Article
- A paintable phosphorescent bandage for postoperative tissue oxygen assessment in DIEP flap reconstruction.Science advances · 2020Article
- Quantifying dermal microcirculatory changes of neuropathic and neuroischemic diabetic foot ulcers using spatial frequency domain imaging: a shade of things to come?BMJ open diabetes research & care · 2020Article
- Rapid tissue oxygenation mapping from snapshot structured-light images with adversarial deep learning.Journal of biomedical optics · 2020Article
- Measurement of optical reflection and temperature changes after blood occlusion using a wearable device.Scientific reports · 2020Article
- Use of New Technologies in Implant-Based Breast Reconstruction.Seminars in plastic surgery · 2019Review
- Real-time optical properties and oxygenation imaging using custom parallel processing in the spatial frequency domain.Biomedical optics express · 2019Article
- Spatial frequency domain imaging in 2019: principles, applications, and perspectives.Journal of biomedical optics · 2019Review
- Single snapshot imaging of optical properties using a single-pixel camera: a simulation study.Journal of biomedical optics · 2019Article
- Review of structured light in diffuse optical imaging.Journal of biomedical optics · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
introductionAlthough various methods exist for monitoring flaps during reconstructive surgery, surgeons primarily rely on assessment of clinical judgment. Early detection of vascular complications improves rate of flap salvage. Spatial frequency domain imaging (SFDI) is a promising new technology that provides oxygenation images over a large field of view. The goal of this clinical pilot study is to use SFDI in perforator flap breast reconstruction.
methodsThree women undergoing unilateral breast reconstruction after mastectomy were enrolled for our study. The SFDI system was deployed in the operating room, and images acquired over the course of the operation. Time points included images of each hemiabdominal skin flap before elevation, the selected flap after perforator dissection, and after microsurgical transfer.
resultsSpatial frequency domain imaging was able to measure tissue oxyhemoglobin concentration (ctO2Hb), tissue deoxyhemoglobin concentration, and tissue oxygen saturation (stO2). Images were created for each metric to monitor flap status and the results quantified throughout the various time points of the procedure. For 2 of 3 patients, the chosen flap had a higher ctO2Hb and stO2. For 1 patient, the chosen flap had lower ctO2Hb and stO2. There were no perfusion deficits observed based on SFDI and clinical follow-up.
conclusionsThe results of our initial human pilot study suggest that SFDI has the potential to provide intraoperative oxygenation images in real-time during surgery. With the use of this technology, surgeons can obtain tissue oxygenation and hemoglobin concentration maps to assist in intraoperative planning; this can potentially prevent complications and improve clinical outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.