ArticleNucleus (Austin, Tex.)
Flexible and dynamic nucleosome fiber in living mammalian cells.
Article in Nucleus (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Enhancer placement impacts transcriptional dynamics in Drosophila embryos.Nature communications · 2026Article
- Brownian dynamics simulations of mesoscale chromatin fibers.Biophysical journal · 2023Article
- Characterization of nucleosome sediments for protein interaction studies by solid-state NMR spectroscopy.Magnetic resonance (Gottingen, Germany) · 2021Article
- High Temporal Resolution 3D Live-Cell Imaging of Budding Yeast Meiosis Defines Discontinuous Actin/Telomere-Mediated Chromosome Motion, Correlated Nuclear Envelope Deformation and Actin Filament Dynamics.Frontiers in cell and developmental biology · 2021Article
- Microrheology for Hi-C Data Reveals the Spectrum of the Dynamic 3D Genome Organization.Biophysical journal · 2020Article
- Monitoring the spatio-temporal organization and dynamics of the genome.Nucleic acids research · 2020Review
- Modes of phase separation affecting chromatin regulation.Open biology · 2019Review
- Organization of fast and slow chromatin revealed by single-nucleosome dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Density imaging of heterochromatin in live cells using orientation-independent-DIC microscopy.Molecular biology of the cell · 2017Article
- Altered chromatin compaction and histone methylation drive non-additive gene expression in an interspecific Arabidopsis hybrid.Genome biology · 2017Article
- Bridging the dynamics and organization of chromatin domains by mathematical modeling.Nucleus (Austin, Tex.) · 2017Article
- Dynamic Nucleosome Movement Provides Structural Information of Topological Chromatin Domains in Living Human Cells.PLoS computational biology · 2016Article
- Intracellular kinetics of the androgen receptor shown by multimodal Image Correlation Spectroscopy (mICS).Scientific reports · 2016Article
- In search of the determinants of enhancer-promoter interaction specificity.Trends in cell biology · 2014Review
- Chromatin as dynamic 10-nm fibers.Chromosoma · 2014Review
- Chromatin without the 30-nm fiber: constrained disorder instead of hierarchical folding.Epigenetics · 2014Review
- Article
- Single cell correlation fractal dimension of chromatin: a framework to interpret 3D single molecule super-resolution.Nucleus (Austin, Tex.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Genomic DNA is organized three dimensionally within cells as chromatin and is searched and read by various proteins by an unknown mechanism; this mediates diverse cell functions. Recently, several pieces of evidence, including our cryomicroscopy and synchrotron X-ray scattering analyses, have demonstrated that chromatin consists of irregularly folded nucleosome fibers without a 30-nm chromatin fiber (i.e., a polymer melt-like structure). This melt-like structure implies a less physically constrained and locally more dynamic state, which may be crucial for protein factors to scan genomic DNA. Using a combined approach of fluorescence correlation spectroscopy, Monte Carlo computer simulations, and single nucleosome imaging, we demonstrated the flexible and dynamic nature of the nucleosome fiber in living mammalian cells. We observed local nucleosome fluctuation (~50 nm movement/30 ms) caused by Brownian motion. Our in vivo/in silico results suggest that local nucleosome dynamics facilitate chromatin accessibility and play a critical role in the scanning of genome information.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.