ArticleRNA biology2013
Proteome-wide analysis reveals clues of complementary interactions between mRNAs and their cognate proteins as the physicochemical foundation of the genetic code.
Article in RNA biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- RNA-binding protein transcripts reflect composition of target mRNAs.Nucleic acids research · 2026Article
- Widespread autogenous mRNA-protein interactions detected by CLIP-seq.Nucleic acids research · 2022Article
- Compositional complementarity between genomic RNA and coat proteins in positive-sense single-stranded RNA viruses.Nucleic acids research · 2022Article
- Evolution of the Standard Genetic Code.Journal of molecular evolution · 2021Article
- RNA polymerase II-binding aptamers in human ACRO1 satellites disrupt transcriptionTranscription · 2020Article
- Circular code motifs in the ribosome: a missing link in the evolution of translation?RNA (New York, N.Y.) · 2019Article
- Integrated transcriptomic and secretomic approaches reveal critical pathogenicity factors in Pseudofabraea citricarpa inciting citrus target spot.Microbial biotechnology · 2019Article
- RNA-protein interactions in an unstructured context.FEBS letters · 2018Review
- The Standard Genetic Code Facilitates Exploration of the Space of Functional Nucleotide Sequences.Journal of molecular evolution · 2018Article
- Triplet-Based Codon Organization Optimizes the Impact of Synonymous Mutation on Nucleic Acid Molecular Dynamics.Journal of molecular evolution · 2018Article
- mRNA/protein sequence complementarity and its determinants: The impact of affinity scales.PLoS computational biology · 2017Article
- Autocatalytic Sets and RNA Secondary Structure.Journal of molecular evolution · 2017Article
- A code within a code: how codons influence mRNA stability.The EMBO journal · 2016Article
- Cross-species conservation of complementary amino acid-ribonucleobase interactions and their potential for ribosome-free encoding.Scientific reports · 2015Article
- Malleable nature of mRNA-protein compositional complementarity and its functional significance.Nucleic acids research · 2015Article
- Revealing the density of encoded functions in a viral RNA.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Absolute binding-free energies between standard RNA/DNA nucleobases and amino-acid sidechain analogs in different environments.Nucleic acids research · 2015Article
- Computational analysis of amino acids and their sidechain analogs in crowded solutions of RNA nucleobases with implications for the mRNA-protein complementarity hypothesis.Nucleic acids research · 2014Article
- On the Contribution of Protein Spatial Organization to the Physicochemical Interconnection between Proteins and Their Cognate mRNAs.Life (Basel, Switzerland) · 2014Article
- Woese on the received view of evolution.RNA biology · 2014Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Despite more than 50 years of effort, the origin of the genetic code remains enigmatic. Among different theories, the stereochemical hypothesis suggests that the code evolved as a consequence of direct interactions between amino acids and appropriate bases. If indeed true, such physicochemical foundation of the mRNA/protein relationship could also potentially lead to novel principles of protein-mRNA interactions in general. Inspired by this promise, we have recently explored the connection between the physicochemical properties of mRNAs and their cognate proteins at the proteome level. Using experimentally and computationally derived measures of solubility of amino acids in aqueous solutions of pyrimidine analogs together with knowledge-based interaction preferences of amino acids for different nucleobases, we have revealed a statistically significant matching between the composition of mRNA coding sequences and the base-binding preferences of their cognate protein sequences. Our findings provide strong support for the stereochemical hypothesis of genetic code's origin and suggest the possibility of direct complementary interactions between mRNAs and cognate proteins even in present-day cells.
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