ArticleBMC infectious diseases2013
Co-infection of human parvovirus B19 with Plasmodium falciparum contributes to malaria disease severity in Gabonese patients.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Human parvovirus B19 infection in dengue patients and potential association with disease progression and clinical outcomes.IJID regions · 2025Article
- The Association of Human Parvovirus B19 Infection on the Course of Vietnamese Patients with Rheumatoid Arthritis.Medicina (Kaunas, Lithuania) · 2025Observational
- Review
- Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda.PloS one · 2019Article
- Coinfections identified from metagenomic analysis of cervical lymph nodes from tularemia patients.BMC infectious diseases · 2018Article
- Genotypes of erythrovirus B19, their geographical distribution & circulation in cases with various clinical manifestations.The Indian journal of medical research · 2018Review
- Prevalence and Genotypes of Parvovirus B19 Among HIV Positive Children in Ibadan, Oyo State, Nigeria.Archives of basic and applied medicine · 2018Article
- Detection of human parvovirus B19 in serum samples from children under 5 years of age with rash-fever illnesses in the Democratic Republic of the Congo.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2017Article
- Influenza A and Parvovirus B19 Seropositivity Rates in Gabonese Infants.The American journal of tropical medicine and hygiene · 2015Article
- Blood Groups in Infection and Host Susceptibility.Clinical microbiology reviews · 2015Review
- Novel B19-like parvovirus in the brain of a harbor seal.PloS one · 2013Article
- Falciparum malaria and parvovirus B19 coinfection: A rare entity.Tropical parasitologyArticle
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10 authors.
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Abstract
backgroundHigh seroprevalence of parvovirus B19 (B19V) coinfection with Plasmodium falciparum has been previously reported. However, the impact of B19V-infection on the clinical course of malaria is still elusive. In this study, we investigated the prevalence and clinical significance of B19V co-infection in Gabonese children with malaria.
methodsB19V prevalence was analyzed in serum samples of 197 Gabonese children with P. falciparum malaria and 85 healthy controls using polymerase chain reaction (PCR), enzyme-linked immunosorbent assay (ELISA), and direct DNA-sequencing.
resultsB19V was detected in 29/282 (10.28%) of Gabonese children. B19V was observed more frequently in P. falciparum malaria patients (14.21%) in comparison to healthy individuals (1.17%) (P<0.001). Notably, the mild-malaria group revealed significantly lower hematocrit levels in B19V/P. falciparum co-infection than in P. falciparum mono-infection (P<0.05). Genetic analysis revealed a predominance of B19V genotype-1 (71.43%) in the studied population. However, B19V-genotype 2 was observed significantly more often in children with severe-malaria than in mild-malaria (P=0.04).
conclusionOur findings reveal that B19V-infection is frequent in Gabonese children with P. falciparum malaria and signifies a possible contribution of B19V on the clinical course of malaria in a genotype-dependent manner. B19V co-infection should be considered as a additional diagnostic measure in malaria patients with life threatening anemia.
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