Evidence map›Paper›PMID 23944194›Full record

Trial reportJournal of clinical and experimental neuropsychology2013

Effect of armodafinil on cognition in patients with HIV/AIDS and fatigue.

Martin McElhiney, Judith Rabkin, Wilfred Van Gorp, Richard Rabkin

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of clinical and experimental neuropsychology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pharmacological treatments for fatigue associated with palliative care.The Cochrane database of systematic reviews · 2015
    Pooled it
  2. Article
  3. Review
  4. Fatigue in HIV-Infected People: A Three-Year Observational Study.Journal of pain and symptom management · 2015
    Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Martin McElhineya Department of Psychiatry , College of Physicians and Surgeons, Columbia University , New York , NY , USA.
Judith Rabkin
Wilfred Van Gorp
Richard Rabkin
New York State Psychiatric InstituteColumbia University · USNew York Psychoanalytic Society and Institute · US

Funding

The Statistics, Data Science, and Data Management (SDM) CoreP30MH043520 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MILTON L WAINBERG · 2003 to 2026
$48.2M
Modafinil Treatment for Fatigue in HIV+ PatientsR01MH072383 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI RABKIN, JUDITH G. · 2005 to 2008
$1.3M
NIMH NIH HHS P30 MH043520NIMH NIH HHS R01 MH072383
6 · The paper itself

Abstract

Fatigue and cognitive impairment are common in HIV+ adults and may occur independently or be causally linked. This study examined whether alleviation of fatigue with armodafinil in a placebo-controlled double-blind 4-week trial had an effect on cognitive function among those with and without mild neuropsychological impairment at baseline. Sixty-one patients completed a standard battery of neuropsychological tests at study entry and Week 4: A total of 33 were randomized to armodafinil and 28 to placebo. While there was a significant effect of active medication on fatigue, cognitive performance measured by a global change score did not differ between treatment groups, or in those on active treatment with or without mild neuropsychological impairment.

Indexed as

Acquired Immunodeficiency SyndromeAdultAgedBenzhydryl CompoundsCD4 Lymphocyte CountCentral Nervous System StimulantsCognitionCognition DisordersData Interpretation, StatisticalDiagnostic and Statistical Manual of Mental DisordersDouble-Blind MethodEmploymentFatigueFemaleHepatitis CHIVBenzhydryl CompoundsCentral Nervous System StimulantsModafinilRNA, Viral

Identifiers

PMID23944194
PMCPMC3781217
OpenAlexW2129627577

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.