ArticleThe Plant cell2013
Arabidopsis basic helix-loop-helix transcription factors MYC2, MYC3, and MYC4 regulate glucosinolate biosynthesis, insect performance, and feeding behavior.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 272 papers.
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Who cites it
272 citing papers in PubMed, 536 citations in OpenAlex.
- Sulfur as a central integrator of plant-microbe interactions: from nutrient cycling to immune signalling and microbiome assembly.Journal of experimental botany · 2026Review
- Molecular and transcriptional regulation of plant defense responses to aphid infestation.Stress biology · 2026Review
- Review
- BoOFP6 Negatively Regulates Glucosinolates Accumulation in Broccoli Sprouts by Cytoplasmic Sequestration of BoMYB34-3.Plant, cell & environment · 2026Article
- ATML1-GIR1-TPL/TPR transcriptional repression module controls glucosinolates and giant cells inbioRxiv : the preprint server for biology · 2026Article
- BnaA07.SUC2 regulated by BnaA05.MYC2 in jasmonate pathway promotes oilseed rape susceptibility to Plasmodiophora brassicae.PLoS pathogens · 2026Article
- Glucosinolates inInternational journal of molecular sciences · 2026Review
- Article
- Overexpression of GhAAP3 increases Helicoverpa armigera feeding by altering hormonal and metabolic composition in cotton.Plant cell reports · 2026Article
- Vernalization attenuates age-dependent decline of glucosinolates in cabbage (Brassica oleracea ssp. capitata) through coordinated transcriptomic and metabolomic reprogramming.BMC plant biology · 2026Article
- Genome-wide identification of MYC transcription factors in Chrysanthemum morifolium and CmMYC25 promotes petal anthocyanin accumulation.Plant cell reports · 2026Article
- Glucosinolate variation, heterosis, and prediction of hybrid performance from parental values in white cabbage (Frontiers in plant science · 2026Article
- Creating a new oilseed crop, pennycress, by combining key domestication traits using CRISPR genome editing.Nature plants · 2026Article
- Regulatory mechanisms of amino acid metabolic pathways in Rhododendron chrysanthum Pall. Under UV-B stress.PloS one · 2026Article
- Long-term methyl jasmonate exposure triggers COI1-independent induction of myrosinasesFrontiers in plant science · 2026Article
- A natural variant of anProceedings of the National Academy of Sciences of the United States of America · 2025Article
- MYC2a/b-regulated protease inhibitors in defense against Spodoptera litura in Nicotiana attenuata.Plant cell reports · 2025Article
- Transcriptome and small RNA sequencings reveal the response of tobacco to aphid infestation.BMC genomics · 2025Article
- ABC1K2 is involved in stress response and secondary metabolism during seed development in Arabidopsis thaliana.Plant cell reports · 2025Article
- CRISPR/Cas9-mediated mutation of GhCAD decreases the gossypol content of cottonseed.Journal of biological engineering · 2025Article
212 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Arabidopsis thaliana plants fend off insect attack by constitutive and inducible production of toxic metabolites, such as glucosinolates (GSs). A triple mutant lacking MYC2, MYC3, and MYC4, three basic helix-loop-helix transcription factors that are known to additively control jasmonate-related defense responses, was shown to have a highly reduced expression of GS biosynthesis genes. The myc2 myc3 myc4 (myc234) triple mutant was almost completely devoid of GS and was extremely susceptible to the generalist herbivore Spodoptera littoralis. On the contrary, the specialist Pieris brassicae was unaffected by the presence of GS and preferred to feed on wild-type plants. In addition, lack of GS in myc234 drastically modified S. littoralis feeding behavior. Surprisingly, the expression of MYB factors known to regulate GS biosynthesis genes was not altered in myc234, suggesting that MYC2/MYC3/MYC4 are necessary for direct transcriptional activation of GS biosynthesis genes. To support this, chromatin immunoprecipitation analysis showed that MYC2 binds directly to the promoter of several GS biosynthesis genes in vivo. Furthermore, yeast two-hybrid and pull-down experiments indicated that MYC2/MYC3/MYC4 interact directly with GS-related MYBs. This specific MYC-MYB interaction plays a crucial role in the regulation of defense secondary metabolite production and underlines the importance of GS in shaping plant interactions with adapted and nonadapted herbivores.
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