ArticleThe Plant cell2013
Predicting gene function from uncontrolled expression variation among individual wild-type Arabidopsis plants.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Robustness in jasmonate signaling: mechanisms of concerted regulation and implications for crop improvement.aBIOTECH · 2025Review
- Bet-hedging and variability in plant development: seed germination and beyond.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Plant competition cues activate a singlet oxygen signaling pathway inFrontiers in plant science · 2024Article
- Predicting yield of individual field-grown rapeseed plants from rosette-stage leaf gene expression.PLoS computational biology · 2023Article
- mGenome biology · 2022Article
- Phytochrome B regulates jasmonic acid-mediated defense response againstPlant diversity · 2022Article
- Metabolism, signaling, and transport of jasmonates.Plant communications · 2021Review
- Differential Regulation of the Ribosomal Association of mRNA Transcripts in anFrontiers in plant science · 2021Article
- Using single-plant-omics in the field to link maize genes to functions and phenotypes.Molecular systems biology · 2020Article
- Co-expression Networks From Gene Expression Variability Between Genetically Identical Seedlings Can Reveal Novel Regulatory Relationships.Frontiers in plant science · 2020Article
- Widespread inter-individual gene expression variability inMolecular systems biology · 2019Article
- The fungal phytotoxin lasiojasmonate A activates the plant jasmonic acid pathway.Journal of experimental botany · 2018Article
- Coordinated Functional Divergence of Genes after Genome Duplication inThe Plant cell · 2017Article
- Strategies and tools to improve crop productivity by targeting photosynthesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Regulation of growth-defense balance by the JASMONATE ZIM-DOMAIN (JAZ)-MYC transcriptional module.The New phytologist · 2017Article
- Article
- Microarray analysis of Arabidopsis WRKY33 mutants in response to the necrotrophic fungus Botrytis cinerea.PloS one · 2017Article
- Population transcriptomics uncovers the regulation of gene expression variation in adaptation to changing environment.Scientific reports · 2016Article
- Hormone crosstalk in wound stress response: wound-inducible amidohydrolases can simultaneously regulate jasmonate and auxin homeostasis in Arabidopsis thaliana.Journal of experimental botany · 2016Article
- Functional Characterization of CYP94-Genes and Identification of a Novel Jasmonate Catabolite in Flowers.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Gene expression profiling studies are usually performed on pooled samples grown under tightly controlled experimental conditions to suppress variability among individuals and increase experimental reproducibility. In addition, to mask unwanted residual effects, the samples are often subjected to relatively harsh treatments that are unrealistic in a natural context. Here, we show that expression variations among individual wild-type Arabidopsis thaliana plants grown under the same macroscopic growth conditions contain as much information on the underlying gene network structure as expression profiles of pooled plant samples under controlled experimental perturbations. We advocate the use of subtle uncontrolled variations in gene expression between individuals to uncover functional links between genes and unravel regulatory influences. As a case study, we use this approach to identify ILL6 as a new regulatory component of the jasmonate response pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.