ArticlePhysiological genomics2013
Human angiotensinogen +11525 C/A polymorphism modulates its gene expression through microRNA binding.
Article in Physiological genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
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- Genetic Variations inJournal of clinical medicine · 2023Article
- Article
- Transcriptome analysis of arterial and venous circulating miRNAs during hypertension.Scientific reports · 2021Article
- A polymorphism in intron I of the human angiotensinogen gene (The Journal of biological chemistry · 2019Article
- A new model of the mechanism underlying lead poisoning: SNP in miRNA target region influence the AGT expression level.Hereditas · 2019Article
- A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans.Journal of personalized medicine · 2018Article
- A functional variant in ST2 gene is associated with risk of hypertension via interfering MiR-202-3p.Journal of cellular and molecular medicine · 2017Article
- A novel role for miR-133a in centrally mediated activation of the renin-angiotensin system in congestive heart failure.American journal of physiology. Heart and circulatory physiology · 2017Article
- Hypertensive epigenetics: from DNA methylation to microRNAs.Journal of human hypertension · 2015Review
- Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes.Genes & nutrition · 2015Article
- Non-coding RNAs and hypertension-unveiling unexpected mechanisms of hypertension by the dark matter of the genome.Current hypertension reviews · 2015Review
- Novel insights into miRNA in lung and heart inflammatory diseases.Mediators of inflammation · 2014Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hypertension is a serious risk factor for cardiovascular disease. Like other complex disease, hypertension is caused by a combination of genetic and environmental factors. The renin-angiotensin system plays an important role in the regulation of blood pressure. Angiotensinogen (AGT) gene is associated with essential hypertension in Caucasians, Japanese, and Asian-Indian subjects. AGT gene may also be associated with cardiac hypertrophy, coronary atherosclerosis, and microangiopathy related cerebral damage. Human AGT gene has a C/A polymorphism at nucleoside 11525 (rs7079) that is located in the 3'-untranslated region (3'-UTR) and is modestly associated with increased blood pressure. We show here that miR-31 and miR-584 bind strongly to the hAGT 3'-UTR containing 11525C allele compared with 11525A allele. We also show that transfection of miR-31 and miR-584 downregulates the hAGT mRNA and protein levels in human liver cells. These studies may provide new therapeutic approach to reduce hypertension.
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