ArticleInternal and emergency medicine2014
A prospective study on survival in cancer patients with and without venous thromboembolism.
Article in Internal and emergency medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Correlation between ALK+ non-small cell lung cancer targeted therapy and thrombosis: a systematic review and network meta-analysis.BMJ open · 2024Pooled it
- Venous thromboembolism and mortality in breast cancer: cohort study with systematic review and meta-analysis.BMC cancer · 2017Pooled it
- Pooled it
- Development and validation of a preoperative nomogram for predicting venous thromboembolism risk after gynecologic oncology surgery.Discover oncology · 2026Article
- Management of Spontaneous Aortic Thrombus Following Cisplatin-Based Chemotherapy in Urothelial Cancer: A Case Report.Vascular specialist international · 2023Article
- Ambulatory cancer patients: who should definitely receive antithrombotic prophylaxis and who should never receive.Internal and emergency medicine · 2023Review
- The association between two genetic polymorphisms inSaudi journal of biological sciences · 2022Article
- The Application of Current Proposed Venous Thromboembolism Risk Assessment Model for Ambulatory Patients With Cancer.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Article
- Thromboembolic events in cancer patients on active treatment with cisplatin-based chemotherapy: another look!Thrombosis journal · 2018Article
- Prediction of venous thromboembolism in newly diagnosed patients treated for lymphoid malignancies: validation of the Khorana Risk Score.Medical oncology (Northwood, London, England) · 2017Article
- Risk factors and prognosis value of venous thromboembolism in patients with advanced non-small cell lung cancer: a case-control study.Journal of thoracic disease · 2017Article
- Temporal trends in initiation of VKA, rivaroxaban, apixaban and dabigatran for the treatment of venous thromboembolism - A Danish nationwide cohort study.Scientific reports · 2017Article
- Mutational status predicts the risk of thromboembolic events in lung adenocarcinoma.Multidisciplinary respiratory medicine · 2017Article
- Clinical presentation and in-hospital death in acute pulmonary embolism: does cancer matter?Internal and emergency medicine · 2016Article
- Pros and cons of new oral anticoagulants in the treatment of venous thromboembolism in patients with cancer.Internal and emergency medicine · 2015Article
- Venous thromboembolism risk factors in Chinese non-small cell lung cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015Article
- Impact of venous thromboembolism on survival in patients with advanced cancer: an unmet clinical need.Internal and emergency medicine · 2014Article
- Cardiovascular oncology: a new discipline inside internal medicine?Internal and emergency medicine · 2014Article
- Unsuspected pulmonary embolism in cancer patients: a narrative review with pooled data.Internal and emergency medicine · 2014Review
- Incidence and Determinants of Chemotherapy Associated Thromboembolic Events among Ethiopian Patients Treated for Solid Malignancy: A Retrospective Cross-Sectional Study.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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No grant is acknowledged in the PubMed record.
Abstract
Retrospective population-based studies showed that in cancer patients venous thromboembolism (VTE) is associated with reduced survival. Master Oncology is a multicenter study in patients with solid advanced cancer aimed at assessing (1) risk factors for VTE using a case-control design, and (2) survival in cases (patients with VTE) and controls (patients without VTE). Survival data were prospectively collected for at least 10 months. Overall, 237 cases and 339 controls were included in the analysis. The following factors were found to be associated with an increased risk of VTE: body mass index (BMI; OR 2.02; 95% CI 1.31-3.12 for ≥26 vs. <23 kg/m(2)), ECOG score (OR 2.14; 95% CI 1.47-3.11 for grade 1, and 3.32; 95% CI 1.64-6.00 for grade 2-3, compared to grade 0) and recent diagnosis of cancer (OR 1.90; 95% CI 1.33-2.71 for <12 vs. ≥12 months). After an average prospective observation of 8.3 months, 136 cases (57.4%) and 127 controls (37.5%) died with a median survival of 8.7 (95% CI 7.5-10.9) and 14.3 months (95% CI 12.2-18.7), respectively, (Wilcoxon = 27.72, p < 0.001; multivariate hazard ratio 1.55; 95% CI 1.21-2.00). Median survival time was reduced for both patients with symptomatic (Wilcoxon = 35.22, p < 0.001) and asymptomatic VTE (Wilcoxon = 4.63, p = 0.031). Patients with advanced solid cancer, high BMI, high ECOG score, and recent diagnosis of cancer are associated with an increased risk for VTE. Patients with both symptomatic and asymptomatic VTE have a reduced survival compared to those without VTE.
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