ArticleJournal of general internal medicine2014
Non-traditional risk factors are important contributors to the racial disparity in diabetes risk: the atherosclerosis risk in communities study.
Article in Journal of general internal medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 37 citations in OpenAlex.
- Differences in substrate metabolism between African American and Caucasian infants: evidence from mesenchymal stem cells.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Multi-dimensional characterization of prediabetes in the Project Baseline Health Study.Cardiovascular diabetology · 2022Observational
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- Vitamin D Deficiency in Patients with Diabetes in French Guiana: Epidemiology and Relation with Microvascular and Macrovascular Complications.Nutrients · 2021Article
- Association between somatostatin analogues and diabetes mellitus in gastroenteropancreatic neuroendocrine tumor patients: A Surveillance, Epidemiology, and End Results-Medicare analysis of 5235 patients.Cancer reports (Hoboken, N.J.) · 2021Article
- Sex Differences in Factors Contributing to the Racial Disparity in Diabetes Risk.American journal of preventive medicine · 2021Article
- Investigating Denominational and Church Attendance Differences in Obesity and Diabetes in Black Christian Men and Women.Journal of religion and health · 2020Article
- Longitudinal Associations Between Body Mass Index During Young Adulthood, Subsequent Weight Change, and Incident Diabetes During Mid- and Older-Adulthood in Non-Hispanic White and African American Populations: The Atherosclerosis Risk in Communities Study.Metabolic syndrome and related disorders · 2020Article
- Disparities in insulin resistance between black and white adults in the United States: The role of lifespan stress exposure.Psychoneuroendocrinology · 2019Article
- Metabolomics Identifies Novel Blood Biomarkers of Pulmonary Function and COPD in the General Population.Metabolites · 2019Article
- Influence of obesity, parental history of diabetes, and genes in type 2 diabetes: A case-control study.Scientific reports · 2019Article
- Shared and unique risk factors for depression and diabetes mellitus in a longitudinal study, implications for prevention: an analysis of a longitudinal population sample aged ⩾45 years.Therapeutic advances in endocrinology and metabolism · 2019Article
- Survival-related Selection Bias in Studies of Racial Health Disparities: The Importance of the Target Population and Study Design.Epidemiology (Cambridge, Mass.) · 2018Article
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- Article
- Socioeconomic, health, and psychosocial mediators of racial disparities in cognition in early, middle, and late adulthood.Psychology and aging · 2017Article
- Serum potassium is a predictor of incident diabetes in African Americans with normal aldosterone: the Jackson Heart Study.The American journal of clinical nutrition · 2017Observational
- Serum calcium and its complex association with incident type 2 diabetes.The American journal of clinical nutrition · 2016Article
- Article
- Racial-ethnic disparities in the association between risk factors and diabetes: The Northern Manhattan Study.Preventive medicine · 2016Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundTraditional risk factors, particularly obesity, do not completely explain the excess risk of diabetes among African Americans compared to whites.
objectiveWe sought to quantify the impact of recently identified, non-traditional risk factors on the racial disparity in diabetes risk.
designProspective cohort study.
participantsWe analyzed data from 2,322 African-American and 8,840 white participants without diabetes at baseline from the Atherosclerosis Risk in Communities (ARIC) Study. MAIN MEASURES: We used Cox regression to quantify the association of incident diabetes by race over 9 years of in-person and 17 years of telephone follow-up, adjusting for traditional and non-traditional risk factors based on literature search. We calculated the mediation effect of a covariate as the percent change in the coefficient of race in multivariate models without and with the covariate of interest; 95 % confidence intervals (95 % CI) were calculated using boot-strapping. KEY
resultsAfrican American race was independently associated with incident diabetes. Body mass index (BMI), forced vital capacity (FVC), systolic blood pressure, and serum potassium had the greatest explanatory effects for the difference in diabetes risk between races, with mediation effects (95 % CI) of 22.0 % (11.7 %, 42.2 %), 21.7 %(9.5 %, 43.1 %), 17.9 % (10.2 %, 37.4 %) and 17.7 % (8.2 %, 39.4 %), respectively, during 9 years of in-person follow-up, with continued effect over 17 years of telephone follow-up.
conclusionsNon-traditional risk factors, particularly FVC and serum potassium, are potential mediators of the association between race and diabetes risk. They should be studied further to verify their importance and to determine if they mark causal relationships that can be addressed to reduce the racial disparity in diabetes risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.