ArticleSchizophrenia bulletin2014
Mortality in schizophrenia: clinical and serological predictors.
Article in Schizophrenia bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Worldwide prevalence of suicidal ideation and suicide plan among people with schizophrenia: a meta-analysis and systematic review of epidemiological surveys.Translational psychiatry · 2021Pooled it
- Protein-C Reactive as Biomarker Predictor of Schizophrenia Phases of Illness? A Systematic Review.Current neuropharmacology · 2018Pooled it
- Cardiovascular risk factors and metabolic syndrome in people with established psychotic illnesses: baseline data from the IMPaCT randomized controlled trial.Psychological medicine · 2015Trial
- Smoking Cessation in Individuals With Serious Mental Illness: A Randomized Controlled Trial of Two Psychosocial Interventions.Journal of dual diagnosis · 2015Trial
- The intermediate role of impulsive personality traits between attention-deficit/hyperactivity disorder symptoms and suicidal ideation among patients with schizophrenia.PCN reports : psychiatry and clinical neurosciences · 2026Article
- Risk factors for unnatural mortality in persons with serious mental illness.Scientific reports · 2025Article
- The associations of suicidal ideation with psychopathology and inflammatory cytokines in patients with chronic schizophrenia.BMC psychiatry · 2025Article
- 'I would have killed myself had it not been for this service': qualitative experiences of NHS and third sector crisis care in the UK.BJPsych open · 2025Article
- White matter lipidome alterations in the schizophrenia brain.Schizophrenia (Heidelberg, Germany) · 2024Article
- Complement-dependent loss of inhibitory synapses on pyramidal neurons following Toxoplasma gondii infection.Journal of neurochemistry · 2024Article
- Interventions for smoking cessation in inpatient psychiatry settings.The Cochrane database of systematic reviews · 2024Article
- Cigarette smoking is associated with Herpesviruses in persons with and without serious mental illness.PloS one · 2023Article
- Latent Profiles of Premorbid Adjustment in Schizophrenia and Their Correlation with Measures of Recovery.Journal of clinical medicine · 2022Article
- Mortality in people with schizophrenia: a systematic review and meta-analysis of relative risk and aggravating or attenuating factors.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022Article
- The association between family history and genomic burden with schizophrenia mortality: a Swedish population-based register and genetic sample study.Translational psychiatry · 2021Article
- Article
- Effect of lifestyle, medication and ethnicity on cardiometabolic risk in the year following the first episode of psychosis: prospective cohort study.The British journal of psychiatry : the journal of mental science · 2019Observational
- Factors Affecting the Management of Somatic Comorbidity in Tunisian Patients with Schizophrenia.The Psychiatric quarterly · 2019Article
- Antibodies in the Diagnosis, Prognosis, and Prediction of Psychotic Disorders.Schizophrenia bulletin · 2019Review
- Long-term antipsychotic polypharmacy prescribing in secondary mental health care and the risk of mortality.Acta psychiatrica Scandinavica · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persons with schizophrenia have a reduced life expectancy largely due to death from natural causes. Factors that have been previously associated with excess mortality include cigarette smoking and antipsychotic medication. The role of other environmental factors such as exposure to infectious agents has been the subject of only limited investigation. We prospectively assessed a cohort of persons with schizophrenia with a clinical evaluation and a blood sample from which antibodies to human herpes viruses and Toxoplasma gondii were measured. Mortality was determined with data from the National Death Index following a period of up to 11 years. We examined the role of demographic, serological, and clinical factors on mortality. A total of 25 (5%) of 517 persons died of natural causes. The standardized mortality ratio was 2.80 (95% CI 0.89, 6.38). After adjusting for age and gender, mortality from natural causes was predicted in separate models by cigarette smoking (relative risk [RR] = 4.66, P = .0029); lower cognitive score (RR = 0.96, P = .013); level of antibodies to Epstein-Barr virus (RR = 1.22, P = .0041) and to Herpes Simplex virus type 1 (RR = 1.19, P = .030); immunologic disease (RR = 3.14, P = .044); and genitourinary disease (RR = 2.70; P = .035). Because cigarette smoking confers an almost 5-fold risk of mortality, smoking cessation is an urgent priority. Having an elevated level of antibodies to Epstein-Barr virus and to Herpes Simplex virus type 1 are also significant predictors of death from natural causes.
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