ArticleInfection2013
Risk factors for false-negative results of T-SPOT.TB and tuberculin skin test in extrapulmonary tuberculosis.
Article in Infection, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Interferon-γ release assay and mantoux response in infants with tuberculous meningitis in low and intermediate burden countries.BMC infectious diseases · 2023Pooled it
- Comparison of QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST) for diagnosis of latent tuberculosis in haemodialysis (HD) patients: a meta-analysis of κ estimates.Epidemiology and infection · 2017Pooled it
- Pooled it
- Miliary TB Without Microbiological Confirmation in a Post-Menopausal Female: A Case From a High-Burden Region.Clinical case reports · 2025Article
- Tuberculosis of Rib: Diagnosis and Treatment.Journal of orthopaedic case reports · 2025Article
- Tuberculosis Peritonitis During Treatment of Polycythemia Vera with Ruxolitinib.Infection and drug resistance · 2020Article
- Risk Factors for False-Negative Interferon-γ Release Assay Results in Culture-Confirmed Childhood TB.The American journal of tropical medicine and hygiene · 2019Article
- Evaluation of risk factors for false-negative results with an antigen-specific peripheral blood-based quantitative T cell assay (T-SPOTThe Journal of international medical research · 2018Article
- Prospective Comparison of QFT-GIT and T-SPOT.TB Assays for Diagnosis of Active Tuberculosis.Scientific reports · 2018Article
- The risk factor of false-negative and false-positive for T-SPOT.TB in active tuberculosis.Journal of clinical laboratory analysis · 2018Article
- Application Values of T-SPOT.TB in Clinical Rapid Diagnosis of Tuberculosis.Iranian journal of public health · 2018Article
- A scoring system to effectively evaluate central nervous system tuberculosis in patients with military tuberculosis.PloS one · 2017Observational
- Hepatic and Intra-abdominal Tuberculosis: 2016 Update.Current infectious disease reports · 2016Review
- Comparison of the Sensitivity of QuantiFERON-TB Gold In-Tube and T-SPOT.TB According to Patient Age.PloS one · 2016Article
- Ocular Tuberculosis--A Clinical Conundrum.Ocular immunology and inflammation · 2016Article
- Diagnostic Usefulness of IFN-Gamma Releasing Assays Compared With Conventional Tests in Patients With Disseminated Tuberculosis.Medicine · 2015Observational
- Diagnostic Value of T-Cell Interferon-γ Release Assays on Cerebrospinal Fluid for Tuberculous Meningitis.PloS one · 2015Article
- Do the tuberculin skin test and the QuantiFERON-TB Gold in-tube test agree in detecting latent tuberculosis among high-risk contacts? A systematic review and meta-analysis.Epidemiology and health · 2015Review
- Is the sensitivity of the QuantiFERON-TB gold in-tube test lower than that of T-SPOT.TB in patients with miliary tuberculosis?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Article
- The performance and limitation of T-SPOT.TB for the diagnosis of TB in a high prevalence setting.Journal of thoracic disease · 2014Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeT-SPOT.TB, a recently developed T cell-based assay, has shown promise in diagnosing extrapulmonary tuberculosis (EPTB). However, a limited number of reports have compared the risk factors for false-negative results of tuberculin skin tests (TSTs) and T-SPOT.TB assays in patients with EPTB. We, thus, conducted a prospective, blinded, observational study to evaluate the risk factors for false-negative T-SPOT.TB and TST results in patients with EPTB.
methodsBetween April 2008 and November 2011, all adult patients with suspected EPTB were prospectively enrolled at Asan Medical Center, Seoul, South Korea (an intermediate TB-burden country). Only patients with confirmed and probable EPTB who underwent TST and T-SPOT.TB were included in the final analysis.
resultsOf the 324 patients who underwent both TST and T-SPOT.TB testing, 128 patients with 96 (75 %) culture- or polymerase chain reaction (PCR)-confirmed and 32 (25 %) probable EPTB were finally analyzed. T-SPOT.TB assays were less likely to yield false-negative results than TSTs [17 % (22/128) vs. 54 % (69/128), p < 0.001]. In a multivariate analysis, miliary TB was associated with false-negative TSTs [odds ratio (OR) = 5.3; 95 % confidence interval (CI) 1.7-16.1], while immunosuppression showed a trend toward false-negative TSTs (OR = 2.5; 95 % CI 0.9-6.8). Conversely, lymph node TB (OR = 0.2; 95 % CI 0.1-0.5) and skeletal TB (OR = 0.2; 95 % CI 0.1-0.5) were associated with true-positive TST results. The only risk factor for false-negative T-SPOT.TB results was TB meningitis (OR = 2.6; 95 % CI 1.0-6.6).
conclusionsOur findings suggest that T-SPOT.TB has a better sensitivity to diagnose EPTB than TST, especially in patients with immunosuppression or miliary TB.
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