ArticleAnnals of biomedical engineering2014
Cellularized microcarriers as adhesive building blocks for fabrication of tubular tissue constructs.
Article in Annals of biomedical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Biofabrication of engineered blood vessels for biomedical applications.Science and technology of advanced materials · 2024Review
- 3D Tissue-Engineered Vascular Drug Screening Platforms: Promise and Considerations.Frontiers in cardiovascular medicine · 2022Review
- Development and Angiogenic Potential of Cell-Derived Microtissues Using Microcarrier-Template.Biomedicines · 2021Article
- Predicting lung mass density of patients with interstitial lung disease and healthy subjects using deep neural network and lung ultrasound surface wave elastography.Journal of the mechanical behavior of biomedical materials · 2020Article
- Low-frequency HIFU induced cancer immunotherapy: tempting challenges and potential opportunities.Cancer biology & medicine · 2019Article
- A Method for High-Throughput Robotic Assembly of Three-Dimensional Vascular Tissue.Tissue engineering. Part A · 2019Article
- The effect of pleural fluid layers on lung surface wave speed measurement: Experimental and numerical studies on a sponge lung phantom.Journal of the mechanical behavior of biomedical materials · 2019Article
- Assembly of Tissue-Engineered Blood Vessels with Spatially Controlled Heterogeneities.Tissue engineering. Part A · 2018Article
- Fabrication of Custom Agarose Wells for Cell Seeding and Tissue Ring Self-assembly Using 3D-Printed Molds.Journal of visualized experiments : JoVE · 2018Article
- An Ultrasound Surface Wave Technique for Assessing Skin and Lung Diseases.Ultrasound in medicine & biology · 2018Article
- Targeted Delivery of Bioactive Molecules for Vascular Intervention and Tissue Engineering.Frontiers in pharmacology · 2018Review
- Cellular Self-Assembly with Microsphere Incorporation for Growth Factor Delivery Within Engineered Vascular Tissue Rings.Tissue engineering. Part A · 2017Article
- A mechanical argument for the differential performance of coronary artery grafts.Journal of the mechanical behavior of biomedical materials · 2016Article
- Using Digital Image Correlation to Characterize Local Strains on Vascular Tissue Specimens.Journal of visualized experiments : JoVE · 2016Article
- Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
To meet demands of vascular reconstruction, there is a need for prosthetic alternatives to natural blood vessels. Here we explored a new conduit fabrication approach. Macroporous, gelatin microcarriers laden with human umbilical vein endothelial cells and aortic smooth muscle cells were dispensed into tubular agarose molds and found to adhere to form living tubular tissues. The ability of cellularized microcarriers to adhere to one another involved cellular and extracellular matrix bridging that included the formation of epithelium-like cell layers lining the lumenal and ablumenal surfaces of the constructs and the deposition of collagen and elastin fibers. The tubular tissues behaved as elastic solids, with a uniaxial mechanical response that is qualitatively similar to that of native vascular tissues and consistent with their elastin and collagen composition. Linearized measures of the mechanical response of the fabricated tubular tissues at both low and high strains were observed to increase with duration of static culture, with no significant loss of stiffness following decellularization. The findings highlight the utility of cellularized macroporous gelatin microcarriers as self-adhering building blocks for the fabrication of living tubular structures.
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Registered trials
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